Search results for: Vinay S. Sharma

Items from 1 to 9 out of 9 results

article

Synthesis, characterization, mesomorphic and biological evaluation of some novel sulphonamide Schiff base derivatives

Rana Jatin R., Vijay B. Patel, Nikhil K. Agarwal, Vinay S. Sharma, more

World Scientific News > 2022 > 163 > 1-15

A Novel series of sulphonamide schiff base compounds obtained from sulfa drugs were synthesized by the reaction of 2,4-dichloro-5-sulfamoylbenzoic acid with aldehydes. The synthesized compounds were characterized by using FT-IR, Mass, 1H NMR and 13C NMR spectroscopy to confirm the chemical structures of synthesized compounds. The sulphonamide Schiff base compounds were tested for anti-bacterial, anti-fungal...

article

Synthesis, Characterization, Mesomorphic Study of Some Novel Sulphonamide Schiff Base Derivatives and their Antimicrobial Evaluation

Jatin R. Rana, Vinay S. Sharma, Nikhil K. Agarwal, Jaimin Panchal, more

World Scientific News > 2022 > 168 > 69-80

The new series of sulphonamide schiff base compounds obtained from sulfa drugs has been synthesized by the reaction of 4,4'-Diaminodiphenyl sulfone with aldehydes. The synthesized compounds were characterized by using FT-IR, Mass spectroscopy to confirm the chemical structures of synthesized compounds. The sulfonamide Schiff base compounds were tested for anti-bacterial, anti-fungal and anti-malarial...

article

Columnar liquid crystals based on the lower rim functionalization on resorcin[4]arene core

Suryajit L. Rathod, Vinay S. Sharma, Hitendra A. Mali, Hitesh M. Parekh

World Scientific News > 2022 > 169 > 43-54

Lower rim functionalized resorcin[4]arene derivatives were synthesized by four different n-alkyl chain spacers. All four derivatives have been characterized by using Fourier transform infrared (FT-IR) and Nuclear magnetic resonance (NMR) spectroscopic technique. The liquid crystalline properties of these synthesized compounds were studied by POM investigation. All derivatives exhibited columnar hexagonal...

article

Synthesis and antimicrobial activity of oxadiazole nucleus containing 2,5-substituted 1,3,4-oxadiazole derivatives

Jayesh L. Gajera, Jignesh K. Sutariya, Rakesh Gothwal, Vinay S. Sharma, more

World Scientific News > 2021 > 162 > 75-86

In this study, we report the synthesis of 2,5-substituted 1,3,4-oxadiazole derivatives using condensation of cyclohexanecarbohydrazide derivatives and carbon disulfide. In present study, we have prepared total seven derivatives based on 1,3,4-oxadiazole core further functionalized with thiol moieties. The structures of synthesized compounds (C1-C9) were confirmed by the 1H NMR, and Mass spectrometry...

article

Selective quantification of lacosamide in human plasma using UPLC–MS/MS: Application to pharmacokinetic study in healthy subjects with different doses

Kirtikumar D. Bharwad, Priyanka A. Shah, Pranav S. Shrivastav, Vinay S. Sharma

Biomedical Chromatography > 34 > 11 > n/a - n/a

A practical, sensitive, and robust UPLC–MS/MS method was developed and validated to quantify lacosamide in human plasma. A simple one‐step protein precipitation was used to extract lacosamide and labeled lacosamide‐13C, D3 as an internal standard (IS) from 150‐μL plasma. The extracts were analyzed on an Eclipse Plus C18 column (50 × 2.1 mm, 1.8 μm) using 0.1% formic acid in water and methanol:acetonitrile...

article

Quantification of fenoprofen in human plasma using UHPLC–tandem mass spectrometry for pharmacokinetic study in healthy subjects

Kirtikumar D. Bharwad, Priyanka A. Shah, Pranav S. Shrivastav, Vinay S. Sharma, more

Biomedical Chromatography > 34 > 1 > n/a - n/a

A rapid, simple and sensitive ultra‐performance liquid chromatography–tandem mass spectrometry (UHPLC–MS/MS) method has been developed to quantify fenoprofen, a nonsteroidal anti‐inflammatory drug in human plasma for a pharmacokinetic study in healthy subjects. Owing to high levels of protein binding, protein precipitation followed by solid‐phase extraction was employed for the extraction of fenoprofen...

article

Synthesis and biological activity of novel sulfonamides derivatives of various heterocyclic compounds

Lakshman R. Meena, Vinay S. Sharma, Pawan Swarnkar

World Scientific News > 2020 > 142 > 120-134

A novel series of Sulfonamide embedded heterocyclic derivatives were synthesized and well characterized by using 1H NMR, 13C NMR and IR spectroscopic techniques. All the new synthesized compounds were evaluated to their anti-bacterial, anti-fungal and anti- malarial activities. Noticeably, compound 5b was the most potent compound in vitro anti-microbial (S. aureus) with a MTCC value of 96 microgram/ml...

article

Synthesis, biological investigations, QSAR and DFT analysis of sulfonamide chalcones as potential: antimicrobial, antifungal and antimalarial agents

Lakshman R. Meena, Vinay S. Sharma, Pawan Swarnkar

World Scientific News > 2020 > 147 > 179-196

Various aromatic aldehydes condense with aryl ketone (N-(4-(phenylsulfonamido)phenyl) acetamide) in presence of aqueous alkaline NaOH to form α, β-unsaturated ketone (N-(4-(N-phenylsulfamoyl)phenyl)cinnamamide derivatives or sulfonamide chalcone derivatives). We were synthesized novel sulfonamides chalcones synthesized through Claisen-Schmidt condensation of aromatic aldehydes and sulfonamide containing...

article

Synthesis and in vitro antimicrobial evaluation of some new chalcones containing vinyl ester group and substituted alkyl chain

Vinay S. Sharma, R. B. Patel

World Scientific News > 2016 > 54 > 240-251

A novel series of chalconyl vinyl ester based derivatives were designed and synthesized. The newly synthesized compounds were studied for efficacy against several bacteria (E.Coli, P.Aeruginosa, S.Aureus, S.Pyogenus) and fungi (C.Albicans, A.Niger, Clavatus) using the broth dilution technique. Chalcones were prepared by treatment of 4-iodo acetophenone with 4-hydroxy benzaldehyde by Claisen-Schimidt...

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ANTI-FUNGAL (3)
ANTI-BACTERIAL (2)
ANTI-MALARIAL (2)
ANTIFUNGAL (2)
SCHIFF BASE (2)
SULFONAMIDE (2)
1-3-4-OXADIAZOLE (1)
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4-DICHLOROBENZOIC ACID (1)
ANTI-MICROBIAL (1)
ANTIBACTERIAL (1)
ANTIBACTERIAL; ANTIFUNGAL; CHALCONE; VINYL ESTER (1)
ANTIMALARIAL (1)
ANTIMICROBIAL (1)
CLAISEN-SCHMIDT CONDENSATION (1)
COLUMNAR PHASE (1)
CYCLOHEXANECARBOHYDRAZIDE (1)
DIAMINODIPHENYL SULFONE (1)
FENOPROFEN (1)
FENOPROFEN‐D3 (1)
HUMAN PLASMA (1)
HUMAN PLASMA, LACOSAMIDE, ONE‐STEP PROTEIN PRECIPITATION, PHARMACOKINETIC STUDY, UPLC–MS/MS (1)
LIQUID CRYSTAL (1)
LIQUID CRYSTALS (1)
PHARMACOKINETIC STUDY (1)
RESORCIN[4]ARENE (1)
SELF-ASSEMBLY (1)
SOLID‐PHASE EXTRACTION (1)
SULFONAMIDE HYBRIDS (1)
SUPRAMOLECULES (1)
UHPLC–MS/MS (1)
Α-Β-UNSATURATED KETONE (1)
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Search results for: Vinay S. Sharma

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