Search results for: Muhammad Yar

Items from 1 to 20 out of 58 results

article

Design and development of thyroxine/heparin releasing affordable cotton dressings to treat chronic wounds

Tayyba Sher Waris, Syed Tahir Abbas Shah, Azra Mehmood, Zohaib Iqbal, more

Journal of Tissue Engineering and Regenerative Medicine > 16 > 5 > 460 - 471

This research on a thyroxine/heparin‐based cotton wound dressing tests angiogenic and wound healing ability of thyroxine/heparin in a chick chorionic allantoic membrane bioassay and in skin wounds in healthy rats. Commercially available cotton dressings were simply loaded with thyroxine/heparin solutions and coated with wax. Prior to undertaking the animal study, we assessed in vitro release of thyroxine/heparin...

article

Developing sulfur‐doped titanium oxide nanoparticles loaded chitosan/cellulose‐based proangiogenic dressings for chronic ulcer and burn wounds healing

Abdur R. Aleem, Lubna Shahzadi, Muhammad Nasir, Pegah Hajivand, more

Journal of Biomedical Materials Research Part B: Applied Biomaterials > 110 > 5 > 1069 - 1081

Development of biomaterials supporting angiogenesis are highly desired in medical applications. In current work, chitosan and cellulose were cross‐linked by using triethyl orthoformate and loaded with sulfur‐doped titanium oxide nanoparticles. A readily available and inexpensive titanium oxide was added as a potential proangiogenic agent based on our group findings and other reports on metal oxide...

chapter

Neurodegenerative diseases and effective drug delivery: A review of challenges and novel therapeutics

Amna Akhtar, Anisa Andleeb, Tayyba Sher Waris, Masoomeh Bazzar, more

1152-1167

The central nervous system (CNS) encompasses the brain and spinal cord and is considered the processing center and the most vital part of human body. The central nervous system (CNS) barriers are crucial interfaces between the CNS and the periphery. Among all these biological barriers, the blood-brain barrier (BBB) strongly impede hurdle for drug transport to brain. It is a semi-permeable diffusion...

article

Mechanochemical Transformation of CF₃ Group: Synthesis of Amides and Schiff Bases

Satenik Mkrtchyan, Michał Jakubczyk, Suneel Lanka, Muhammad Yar, more

Advanced Synthesis & Catalysis > 363 > 24 > 5448 - 5460

We communicate two mild, solvent‐free mechanochemical coupling transformations of CF₃ group with nitro compounds into amides or Schiff bases employing Ytterbia as a catalyst. This process proceeds via C−F bond activation, accompanied with utilisation of Si‐based reductants/oxygen scavengers – reductants of the nitro group. The scope and limitations of the disclosed methodologies are thoroughly studied...

article

Synthesis and wound healing performance of new water‐soluble chitosan derivatives

Lubna Shahzadi, Arshad Jamal, Pegah Hajivand, Nasir Mahmood, more

Journal of Applied Polymer Science > 139 > 10 > n/a - n/a

In present work, an efficient method for the preparation of water‐soluble chitosan (CS) is reported. It is based on simple synthetic method, which is easy to handle and delivered good water solubility. This article describes the effect of various factors such as the concentration of reactants and the amount of solvents on the reactions' outcome as well as cytocompatibility of the resulting water‐soluble...

article

Development of NSAID‐loaded nano‐composite scaffolds for skin tissue engineering applications

Mubashra Zehra, Azra Mehmood, Muhammad Yar, Lubna Shahzadi, more

Journal of Biomedical Materials Research Part B: Applied Biomaterials > 108 > 8 > 3064 - 3075

Scar free healing together with pain management is one of the major considerations in full thickness wound healing. Extensive wounds take longer to heal without any clinical intervention and, hence, need natural or artificial extracellular matrix support for quick skin regeneration. To address these issues, medicated 3D porous biomimetic scaffolds were developed with a unique combination of biopolymers,...

article

Developing affordable and accessible pro‐angiogenic wound dressings; incorporation of 2 deoxy D‐ribose (2dDR) into cotton fibres and wax‐coated cotton fibres

Anisa Andleeb, Serkan Dikici, Tayyaba Sher Waris, Muhammad Mustehsan Bashir, more

Journal of Tissue Engineering and Regenerative Medicine > 14 > 7 > 973 - 988

The absorption capacity of cotton dressings is a critical factor in their widespread use where they help absorb wound exudate. Cotton wax dressings, in contrast, are used for wounds where care is taken to avoid adhesion of dressings to sensitive wounds such as burn injuries. Accordingly, we explored the loading of 2‐deoxy‐D‐ribose (2dDR), a small sugar, which stimulates angiogenesis and wound healing...

article

Graphene oxide functionalized with a Schiff Base for the removal of Pb(II) ions from contaminated water: experimental and modeling approach

Rafi O Zaman Brohi, Muhammad Yar Khuhawar, Rasool Bux Mahar

Journal of Chemical Technology & Biotechnology > 95 > 6 > 1694 - 1704

BACKGROUND The current study suggests an experimental and modeling approach for the adsorptive removal of lead(II) ions from contaminated water sample. The Schiff base reagent, bis(salicylaldehyde)ethylenediimine (Salen) functionalized graphene oxide (GO) was applied as adsorbent. Salen functionalized GO was prepared and characterized using scanning electron microscopy (SEM), energy dispersive X‐ray...

article

Surface characterizations of membranes and electrospun chitosan derivatives by optical speckle analysis

Muhammad Rizwan, Yasaman Ganjkhani, Vahideh Farzam Rad, Maasoomeh Bazzar, more

Surface and Interface Analysis > 52 > 4 > 132 - 139

In this paper, we show that laser speckle pattern provides useful information toward revealing discrimination between nanofibers and membranes. Chitosan materials particularly organosoluble chitosan derivatives have a number of applications. The surface characteristics of these materials are very critical for specific applications. The analysis of laser speckles, both numerical and graphical, includes...

article

Novel chitosan derivative based composite scaffolds with enhanced angiogenesis; potential candidates for healing chronic non-healing wounds

Muhammad Rizwan, Rosiyah Yahya, Aziz Hassan, Muhammad Yar, more

Journal of Materials Science: Materials in Medicine > 2019 > 30 > 6 > 1-11

The success of wound healing depends upon the proper growth of vascular system in time in the damaged tissues. Poor blood supply to wounded tissues or tissue engineered grafts leads to the failure of wound healing or rejection of grafts. In present paper, we report the synthesis of novel organosoluble and pro-angiogenic chitosan derivative (CSD) by the reaction of chitosan with 1,3-dimethylbarbituric...

article

Applications of copper nanoparticles for colorimetric detection of dithiocarbamate pesticides

Saima Ameen Ghoto, Muhammad Yar Khuhawar, Taj Muhammad Jahangir, Jamal ul Din Mangi

Journal of Nanostructure in Chemistry > 2019 > 9 > 2 > 77-93

In this report an expeditious, manageable and uncomplicated advancement has been demonstrated in the field of nanoparticles for sensing dithiocarbamates (DTCs) Ziram, Zineb, and Maneb pesticides in environment and juice samples using cetyltrimethyl ammonium bromide (CTAB)-capped copper nanoparticles (CTAB-Cups) as colorimetric probe. The probe was prepared in aqueous solvent using CTAB and hydrazine...

article

Water quality assessment of Ramser site, Indus Delta, Sindh, Pakistan

Muhammad Yar Khuhawar, Rafi O. Zaman Brohi, Taj Muhammad Jahangir, Muhammad Farooque Lanjwani

Environmental Monitoring and Assessment > 2018 > 190 > 8 > 1-11

Seven representative sampling stations were selected from Indus Delta comprising of (1) Keti Bander, (2) Darya Peer, (3) Kharo Chanr, (4) Jati, (5) Shah Bander, (6) Nariri Dhand and (7) Left Bank Outfall Drain (LBOD) near Rupa Mari. The sampling scheme was repeated seven times during 2014–2015 for 1 year. The samples were analysed for temperature, conductivity, pH, hardness, chloride, alkalinity,...

article

Solid-Phase Microextraction and Determination of Tin Species in Beverages and Food Samples by Using Poly (ε-Caprolactone-b-4-Vinyl Benzyl-g-Dimethyl Amino Ethyl Methacrylate) Polymer in Syringe System: a Multivariate Study

Rizwan Ali Zounr, Mustafa Tuzen, Baki Hazer, Muhammad Yar Khuhawar

Food Analytical Methods > 2018 > 11 > 9 > 2538-2546

A new solid-phase microextraction (SPμE) procedure has been developed for separation and preconcentration of Sn ions by using graphite furnace atomic absorption spectrometry (GFAAS). This technique is based on the complexation of Sn(IV) ions with 1-(2-pyridylazo)-2-naphthol (PAN). The poly (ε-caprolactone-b-4-vinyl benzyl-g-dimethyl amino ethyl methacrylate) polymer (PCL vacr) was used as an adsorbent,...

article

Novel ultrasonic‐assisted deep eutectic solvent‐based dispersive liquid–liquid microextraction for determination of vanadium in food samples by electrothermal atomic absorption spectrometry: A multivariate study

Rizwan Ali Zounr, Mustafa Tuzen, Muhammad Yar Khuhawar

Applied Organometallic Chemistry > 32 > 3 > n/a - n/a

A green, efficient, simple and sensitive pre‐concentration method has been developed for the determination of vanadium(V) in foodstuffs using deep eutectic solvent–ultrasonic‐assisted dispersive liquid–liquid microextraction. In the developed procedure, the extraction of vanadium(V) was achieved using 2‐hydroxy‐3‐methoxybenzaldehyde thiosemicarbazone as a chelating agent, choline chloride–phenol as...

article

Novel pyridine‐2,4,6‐tricarbohydrazide thiourea compounds as small key organic molecules for the potential treatment of type‐2 diabetes mellitus: In vitro studies against yeast α‐ and β‐glucosidase and in silico molecular modeling

Tanzeel Ur. Rehman, Sadaf Riaz, Islam Ullah Khan, Muhammad Ashraf, more

Archiv der Pharmazie > 351 > 1 > n/a - n/a

A range of novel pyridine‐2,4,6‐tricarbohydrazide thiourea compounds (4a–i) were synthesized in good to excellent yields (63–92%). The enzyme inhibitory potentials of these compounds were investigated against α‐ and β‐glucosidases because these enzymes play a crucial role in treating type‐2 diabetes mellitus (T2DM). As compared to the reference compound acarbose (IC₅₀ 38.22 ± 0.12 μM), compounds...

article

Identification of anti-cancer potential of doxazocin: Loading into chitosan based biodegradable hydrogels for on-site delivery to treat cervical cancer

Arshad Jamal, Lubna Shahzadi, Samreen Ahtzaz, Saba Zahid, more

Materials Science and Engineering: C > 2018 > 82 > C > 102-109

In this study, an effective, biocompatible and biodegradable co-polymer comprising of chitosan (CS) and polyvinyl alcohol (PVA) hydrogels, chemically crosslinked and impregnated with doxazocin, is reported. The chemical structural properties of the hydrogels were evaluated by Fourier Transform Infrared spectroscopy (FTIR) and physical properties were analysed by scanning electron microscopy (SEM)...

article

Existence and stability analysis of nonlinear sequential coupled system of Caputo fractional differential equations with integral boundary conditions

Akbar Zada, Muhammad Yar, Tongxing Li

Annales Universitatis Paedagogicae Cracoviensis. Studia Mathematica > 2018 > 17

article

Chitosan/hydroxyapatite (HA)/hydroxypropylmethyl cellulose (HPMC) spongy scaffolds-synthesis and evaluation as potential alveolar bone substitutes

Haffsah Iqbal, Moazzam Ali, Rabia Zeeshan, Zeeshan Mutahir, more

Colloids and Surfaces B: Biointerfaces > 2017 > 160 > C > 553-563

Alveolar bone loss is associated with infections and its augmentation is a pre-requisite for the success of dental implants. In present study, we aim to develop and evaluate novel freeze dried doxycycline loaded chitosan (CS)/hydroxyapatite (HA) spongy scaffolds where hydroxypropylmethyl cellulose (HPMC) was added as a crosslinker. Scaffolds displayed compressive strength of 14MPa/cm³ and 0.34 as...

article

Synthesis of a novel organosoluble, biocompatible, and antibacterial chitosan derivative for biomedical applications

Muhammad Rizwan, Rosiyah Yahya, Aziz Hassan, Muhammad Yar, more

Journal of Applied Polymer Science > 135 > 9 > n/a - n/a

Electrospun materials have a number of applications in the tissue engineering field. However, the limited solubility of chitosan (CS), especially in organic solvents, makes its electrospinning with other synthetic organosoluble polymers impossible. In this article, we report the synthesis of a novel organosoluble derivative of CS through the application of a simple synthetic methodology. CS was reacted...

article

Thyroxin releasing chitosan/collagen based smart hydrogels to stimulate neovascularization

Abdur Raheem Aleem, Lubna Shahzadi, Farah Alvi, Ather Farooq Khan, more

Materials & Design > 2017 > 133 > C > 416-425

The development of new biomaterials with tailored properties is highly desired in tissue engineering field. The neovascularization is essential part of tissue regeneration which provides food and nutrients to cells. There is a real need for proangiogenic biomaterials to assist wound healing. The ideal dressing should be inexpensive and achieve rapid healing with minimal inconvenience to the patient...

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Search results for: Muhammad Yar

Design and development of thyroxine/heparin releasing affordable cotton dressings to treat chronic wounds

Developing sulfur‐doped titanium oxide nanoparticles loaded chitosan/cellulose‐based proangiogenic dressings for chronic ulcer and burn wounds healing

Neurodegenerative diseases and effective drug delivery: A review of challenges and novel therapeutics

Mechanochemical Transformation of CF₃ Group: Synthesis of Amides and Schiff Bases

Synthesis and wound healing performance of new water‐soluble chitosan derivatives

Development of NSAID‐loaded nano‐composite scaffolds for skin tissue engineering applications

Developing affordable and accessible pro‐angiogenic wound dressings; incorporation of 2 deoxy D‐ribose (2dDR) into cotton fibres and wax‐coated cotton fibres

Graphene oxide functionalized with a Schiff Base for the removal of Pb(II) ions from contaminated water: experimental and modeling approach

Surface characterizations of membranes and electrospun chitosan derivatives by optical speckle analysis

Novel chitosan derivative based composite scaffolds with enhanced angiogenesis; potential candidates for healing chronic non-healing wounds

Applications of copper nanoparticles for colorimetric detection of dithiocarbamate pesticides

Water quality assessment of Ramser site, Indus Delta, Sindh, Pakistan

Solid-Phase Microextraction and Determination of Tin Species in Beverages and Food Samples by Using Poly (ε-Caprolactone-b-4-Vinyl Benzyl-g-Dimethyl Amino Ethyl Methacrylate) Polymer in Syringe System: a Multivariate Study

Novel ultrasonic‐assisted deep eutectic solvent‐based dispersive liquid–liquid microextraction for determination of vanadium in food samples by electrothermal atomic absorption spectrometry: A multivariate study

Novel pyridine‐2,4,6‐tricarbohydrazide thiourea compounds as small key organic molecules for the potential treatment of type‐2 diabetes mellitus: In vitro studies against yeast α‐ and β‐glucosidase and in silico molecular modeling

Identification of anti-cancer potential of doxazocin: Loading into chitosan based biodegradable hydrogels for on-site delivery to treat cervical cancer

Existence and stability analysis of nonlinear sequential coupled system of Caputo fractional differential equations with integral boundary conditions

Chitosan/hydroxyapatite (HA)/hydroxypropylmethyl cellulose (HPMC) spongy scaffolds-synthesis and evaluation as potential alveolar bone substitutes

Synthesis of a novel organosoluble, biocompatible, and antibacterial chitosan derivative for biomedical applications

Thyroxin releasing chitosan/collagen based smart hydrogels to stimulate neovascularization

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