Search results for: Artur Kowalik

Items from 1 to 17 out of 17 results

article

Analysis of mutation occurrence in patients with acute myeloid leukaemia using next-generation sequencing

Magdalena Stawiarz, Artur Kowalik

Acta Universitatis Lodziensis. Folia Biologica et Oecologica > 2021 > 17 > 9-9

article

Evaluation of two different mutations in codon 12 of NRAS gene in ulcerated penile mucosal nodular malignant melanoma pT4b of the 90‐year‐old man in perspective of targeted therapy of NRAS‐mutated advanced melanomas

Andrzej Wincewicz, Kinga Hińcza, Krzysztof Ossoliński, Anna Ossolińska, more

Dermatologic Therapy > 33 > 6 > n/a - n/a

article

Poorly differentiated thyroid cancer in the context of the revised 2015 American Thyroid Association Guidelines and the Updated American Joint Committee on Cancer/Tumor‐Node‐Metastasis Staging System (eighth edition)

Agnieszka Walczyk, Janusz Kopczyński, Danuta Gąsior‐Perczak, Iwona Pałyga, more

Clinical Endocrinology > 91 > 2 > 331 - 339

Objective Poorly differentiated thyroid cancer (PDTC) is a rare, but aggressive thyroid cancer (TC) and a main cause of death from non‐anaplastic follicular cell‐derived TC. Assessing the risk of PDTC‐related death and the risk of recurrence is important for clinicians. The recent American Thyroid Association (ATA) 2015 guidelines and the updated 8th edition of the American Joint Committee on Cancer/Tumor‐Node‐Metastasis...

article

Somatic mutation profiling of vulvar cancer: Exploring therapeutic targets

Sebastian Zięba, Artur Kowalik, Kamil Zalewski, Natalia Rusetska, more

Gynecologic Oncology > 2018 > 150 > 3 > 552-561

Vulvar squamous cell carcinoma (VSCC) constitutes over 90% of vulvar cancer. Its pathogenesis can follow two different pathways; high risk human papillomavirus (hrHPV)-dependent and HPV-independent. Due to the rarity of VSCC, molecular mechanisms underlying VSCC development remain largely unknown. The study aimed to identify pathogenic mutations implicated in the two pathways of VSCC development.Using...

article

Response to therapy of papillary thyroid cancer of known BRAF status

Aldona Kowalska, Agnieszka Walczyk, Artur Kowalik, Iwona Pałyga, more

Clinical Endocrinology > 87 > 6 > 815 - 824

Objective A dynamic risk stratification with modified initial estimated risk based on response to therapy and disease course is one of the crucial changes adopted recently by the American Thyroid Association (ATA). This approach focuses on an individualized risk‐adapted approach to the management of differentiated thyroid cancer. The BRAF V600E mutation is the most common genetic alteration in papillary...

article

CTRC gene polymorphism may be a risk factor for pancreatic cancer - preliminary study

Stanislaw Gluszek, Artur Kowalik, Dorota Koziel, Jaroslaw Matykiewicz

Pancreatology > 2017 > 17 > 3(S) > S14

article

Current approaches for avoiding the limitations of circulating tumor cells detection methods—implications for diagnosis and treatment of patients with solid tumors

Artur Kowalik, Magdalena Kowalewska, Stanisław Góźdź

Translational Research > 2017 > 185 > C > 58-84.e15

Eight million people die of cancer each year and 90% of deaths are caused by systemic disease. Circulating tumor cells (CTCs) contribute to the formation of metastases and thus are the subject of extensive research and an abiding interest to biotechnology and pharmaceutical companies. Recent technological advances have resulted in greatly improved CTC detection, enumeration, expansion, and culture...

article

CTRC gene polymorphism (p.G60=; c.180 C > T) in acute pancreatitis

Dorota Koziel, Stanislaw Gluszek, Artur Kowalik, Malgorzata Chlopek

BMC Gastroenterology > 2017 > 17 > 1 > 1-7

Background The aim of the study was to determine the relationship between the presence of p.G60 = polymorphism (c.180C > T; rs497078) CTRC and the incidence together with the clinical course of acute pancreatitis (AP). Methods Two hundred ninety-nine people suffering from AP and 417 healthy volunteers were subjected to the study. DNA was isolated from blood samples. Results CTRC p.G60 = polymorphism...

article

Immobilization and detection of platelet-derived extracellular vesicles on functionalized silicon substrate: cytometric and spectrometric approach

Katarzyna Gajos, Agnieszka Kamińska, Kamil Awsiuk, Adrianna Bajor, more

Analytical and Bioanalytical Chemistry > 2017 > 409 > 4 > 1109-1119

Among the various biomarkers that are used to diagnose or monitor disease, extracellular vesicles (EVs) represent one of the most promising targets in the development of new therapeutic strategies and the application of new diagnostic methods. The detection of circulating platelet-derived microvesicles (PMVs) is a considerable challenge for laboratory diagnostics, especially in the preliminary phase...

article

Influence of CTRC gene polymorphism on the development of acute pancreatitis

Dorota Koziel, Stanislaw Gluszek, Artur Kowalik

Pancreatology > 2016 > 16 > 3(S1) > S8

article

The common G60G variant (c.180C > T) of CTRC is associated with increased risk of chronic pancreatitis in children

Agnieszka Magdalena Rygiel, Alicja Monika Grabarczyk, Grzegorz Oracz, Aleksandra Kujko, more

Pancreatology > 2016 > 16 > 3(S1) > S6

article

Serum levels of unique miR-551-5p and endothelial-specific miR-126a-5p allow discrimination of patients in the early phase of acute pancreatitis

Beata Kuśnierz-Cabala, Ewelina Nowak, Mateusz Sporek, Artur Kowalik, more

Pancreatology > 2015 > 15 > 4 > 344-351

Vascular dysfunction is a severe complication which can cause organ ischemia and damage during acute pancreatitis (AP). Laboratory assessment of AP is based on several routine parameters and does not reflect endothelial dysfunction or organ injury. Recently, small non–protein-coding RNAs (miRNAs) have been introduced to laboratory diagnostics as new biomarkers or predictive parameters. Candidate miRNAs...

article

CHEK2 mutations and the risk of papillary thyroid cancer

Monika Siołek, Cezary Cybulski, Danuta Gąsior‐Perczak, Artur Kowalik, more

International Journal of Cancer > 137 > 3 > 548 - 552

Mutations in the cell cycle checkpoint kinase 2 (CHEK2) tumor suppressor gene are associated with multi‐organ cancer susceptibility including cancers of the breast and prostate. A genetic association between thyroid and breast cancer has been suggested, however little is known about the determinants of this association. To characterize the association of CHEK2 mutations with thyroid cancer, we genotyped...

article

Genetic mutations in SPINK1, CFTR, CTRC genes in acute pancreatitis

Dorota Koziel, Stanislaw Gluszek, Artur Kowalik, Malgorzata Chlopek, more

BMC Gastroenterology > 2015 > 15 > 1 > 1-9

Background Explanation of the ultimate causes of acute and chronic pancreatitis is challenging. Hence, it is necessary to seek various etiological factors, including genetic mutations that may be of importance in triggering recurrence and progression of acute to chronic pancreatitis. The aim of this study was to determine the frequency of genetic mutations in patients with acute pancreatitis and to...

article

Genetic factors in acute pancreatitis

Dorota Koziel, Stanislaw Gluszek, Artur Kowalik, Malgorzata Chlopek

Pancreatology > 2014 > 14 > 3 Supplement 1 > S58

article

The BRAF^V^600E mutation in papillary thyroid microcarcinoma: does the mutation have an impact on clinical outcome?

Agnieszka Walczyk, Aldona Kowalska, Artur Kowalik, Jacek Sygut, more

Clinical Endocrinology > 80 > 6 > 899 - 904

ContextAn activating mutation in the gene BRAF has been correlated with poorer prognosis and more aggressive clinical course in papillary thyroid carcinoma (PTC). We therefore hypothesized that the good prognosis, high 5‐year disease‐free rate and high survival rate of patients with less aggressive papillary thyroid microcarcinoma (pT1aNo‐x) would be associated with a lower incidence of the BRAF^V600E...

article

The frequency of SPINK 1, PRSS 1 and CFTR mutations in acute pancreatitis

Dorota Koziel, Artur Kowalik, Liliana Piecak, Małgorzata Chłopek, more

Pancreatology > 2013 > 13 > 3 Supplement > S55

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