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Phosphors with narrow‐band green emissions and high photoluminescent quantum efficiency (PLQY) are significantly required for backlighting displays with wider color gamut. In this work, two centimeter‐sized manganese (II) halide single crystals TMG2MnCl4 and TMG2MnBr4 (TMG = 1,1,3,3‐tetramethylguanidine) are synthesized, exhibiting bright narrow‐band green emissions with high PLQYs up to 62% and 90%,...
Neuropeptide Y (NPY), as one of the most abundant neuropeptides known, is widely distributed in the central and peripheral nervous system. However, most of the reported NPY‐mimetic peptides are hard to cross the blood–brain barrier, target glioma mitochondria, and achieve self‐assembly nanostructure in situ. Here, based on the α‐helix structure of the novel chiral NPY‐mimetic peptides D/LNPY(14),...
Materials with various single‐transition metal atoms dispersed in nitrogenated carbons (M─N─C, M = Fe, Co, and Ni) are synthesized as cathodes to investigate the electrocatalytic behaviors focusing on their enhancement mechanism for performance of Li–S batteries. Results indicate that the order of both electrocatalytic activity and rate capacity for the M─N─C catalysts is Co > Ni > Fe, and the...
Chemiluminescence immunoassay exhibits high sensitivity and signal‐to‐noise ratio, thus attracting great attention in the early diagnosis and dynamic monitoring of diseases. However, the collection of conventional flash‐type chemiluminescence signal (<5 s) relies heavily on automatic sampling and reading instrument. Herein, a novel core‐satellite multifunctional chemiluminescence immunosensor is...
Improving local bone mineral density (BMD) at fracture‐prone sites of bone is a clinical concern for osteoporotic fracture prevention. In this study, a featured radial extracorporeal shock wave (rESW) responsive nano‐drug delivery system (NDDS) is developed for local treatment. Based on a mechanic simulation, a sequence of hollow zoledronic acid (ZOL)‐contained nanoparticles (HZNs) with controllable...
The carrier concentration in n‐type layered Bi2Te3‐based thermoelectric (TE) material is significantly impacted by the donor‐like effect, which would be further intensified by the nonbasal slip during grain refinement of crushing, milling, and deformation, inducing a big challenge to improve its TE performance and mechanical property simultaneously. In this work, high‐energy refinement and hot‐pressing...
Exosomes are promising new biomarkers for colorectal cancer (CRC) diagnosis, due to their rich biological fingerprints and high level of stability. However, the accurate detection of exosomes with specific surface receptors is limited to clinical application. Herein, an exosome enrichment platform on a 3D porous sponge microfluidic chip is constructed and the exosome capture efficiency of this chip...
Low conductivity over a wide temperature region due to ultra‐slow ion migration dynamics is a key issue in the field of solid‐state electrolytes (SSE), which needs to be solved and improved. Covalent organic frameworks (COFs), a rapidly growing class of porous crystalline materials, emerge as a new research hotspot in the field of SSEs. This is due to their homogeneously dispersed sites and well‐defined...
As a stimulator of interferon gene (STING), cyclic dinucleotide activates a broad cellular immune response for anti‐cancer immunotherapy (CIT). However, the inherent of instability of 2′ 3′‐cyclic‐GMP‐AMP (cGAMP) with poor cellular targeting, rapid clearance, and inefficient transport to the cytoplasm seriously hinders cGAMP potency. Here, a thiolated and Mn2+ coordinated cyclic dinucleotide nanovaccine...
The quest for an all‐organic nanosystem with negligible cytotoxicity and remarkable in vivo tumor theranostic capability is inescapably unending. Hitherto, the landscape of available photothermal agents is dominated by metal‐based nanoparticles (NPs) with attendant in vivo negatives. Here, an all‐organic‐composed theranostic nanosystem with outstanding biocompatibility for fluorescence image‐guided...
Photoacoustic imaging‐guided photothermal therapy in the second near‐infrared (NIR‐II) window shows promise for clinical deep‐penetrating tumor phototheranostics. However, ideal photothermal agents in the NIR‐II window are still rare. Here, the emeraldine salt of polyaniline (PANI‐ES), especially synthesized by a one‐pot enzymatic reaction on sodium bis(2‐ethylhexyl) sulfosuccinate (AOT) vesicle surface...
Hepatocellular carcinoma (HCC) is the third leading cause of cancer‐related death worldwide. The prognosis of HCC remains very poor; thus, an effective treatment remains urgent. Herein, a type of nanomedicine is developed by conjugating Fe@Fe3O4 nanoparticles with ginsenoside Rg3 (NpRg3), which achieves an excellent coupling effect. In the dimethylnitrosamine‐induced HCC model, NpRg3 application significantly...
Targeting programmed cell death protein 1 (PD‐1)/programmed death ligand 1 (PD‐L1) immunologic checkpoint blockade with monoclonal antibodies has achieved recent clinical success in antitumor therapy. However, therapeutic antibodies exhibit several issues such as limited tumor penetration, immunogenicity, and costly production. Here, Bristol‐Myers Squibb nanoparticles (NPs) are prepared using a reprecipitation...
Photothermal therapy (PTT) has been pre‐clinically used in cancer treatment, but incomplete tumor removal and heat endurance of tumor cells could induce significant tumor relapse. In article number 1902636, Xiaolong Liu, Jingfeng Liu, and co‐workers report a programmable antitumor strategy that combines artificially engineered natural killer cells with anti‐heat endurance of DNAzyme as a powerful...
Although photothermal therapy (PTT) is preclinically applied in solid tumor treatment, incomplete tumor removal of PTT and heat endurance of tumor cells induces significant tumor relapse after treatment, therefore lowering the therapeutic efficiency of PTT. Herein, a programmable therapeutic strategy that integrates photothermal therapeutic agents (PTAs), DNAzymes, and artificial engineered natural...
In article number 1901176, Juan Li, Xiaolong Liu, Huanghao Yang, and co‐workers develop a thrombolysis approach for noninvasive, on‐demand and sustained antithrombotic therapy with bioengineered cells, which could be noninvasively and precisely controlled to produce urokinase plasminogen activator (uPA) in situ via an NIR laser to significantly enhance the thrombolysis therapeutic effects by spatiotemporally...
Current antithrombotic therapeutic strategies often suffer from severe post‐thrombotic syndromes (PTS), inconvenient daily subcutaneous injections for a long time and short circulation times accompanied by a dose‐dependent risk of intracranial hemorrhage. Aiming at noninvasive, on‐demand, and sustained antithrombotic therapy, a new thrombolysis approach based on the transgene system has been developed...
Osteoporosis, a common and serious bone disorder affecting aged people and postmenopausal women, is characterized by osteoclast overactivity. One therapeutic strategy is suppressing the bone resorption function of hyperactive osteoclasts, but there is no effective drug in clinical practice so far. Herein, it is demonstrated that fullerenols suppress the bone resorption of osteoclasts by inhibiting...
Smart assemblies have attracted increased interest in various areas, especially in developing novel stimuli‐responsive theranostics. Herein, commercially available, natural tannic acid (TA) and iron oxide nanoparticles (Fe3O4 NPs) are utilized as models to construct smart magnetic assemblies based on polyphenol‐inspired NPs–phenolic self‐assembly between NPs and TA. Interestingly, the magnetic assemblies...
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