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A tubular conduit composed of radially aligned electrospun fibers with gradient is transplanted into the gap of the transected spinal cord. The endogenous neural stem cells in the two ends of spinal cord sense the gradient, and migrate toward the lesion site. This class of gradient scaffolds, presented by J. Dai and co‐workers on page 5009, can potentially be employed for nerve regeneration guidance...
Repair of spinal cord injury will require enhanced recruitment of endogenous neural stem cells (NSCs) from the central canal region to the lesion site to reestablish neural connectivity. The strategy toward this goal is to provide directional cues, e.g., alignment topography and biological gradients from the rostral and caudal ends toward the center. This study demonstrates a facile method for fabrication...
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