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To investigate the use of stem cells as biosensor elements, a novel cell-based light-addressable potentiometric sensor (LAPS) was developed for monitoring cellular beating. Mouse embryonic stem cells were induced to differentiate into cardiomyocytes in vitro. Extracellular field potentials of spontaneously beating cardiomyocytes induced from stem cells were recorded by LAPS in the potential and frequency...
Olfactory system can distinguish thousands of odors. In order to utilize biological olfactory neurons as sensitive material of electronic nose, this article reports an olfactory neurochip as real bionic technique for odorants detection. Effective cultures of olfactory receptor neurons and olfactory bulb cells on the chip have been achieved. Using light-addressable potentiometric sensor (LAPS) as sensing...
A novel numerical design of experimental analysis of cell-based sensors was introduced in the paper. In order to increase the signals to noise ratio and improve the performance of the chips, we analyzed cell-based sensors numerically and experimentally. Since the action potential which is about dozens of milliseconds changes quickly, we demonstrated an improved equivalent circuit model. Based on modeling...
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