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We conducted a phase II study using docetaxel and trastuzumab as preoperative systemic treatment for locally advanced HER-2-overexpressing breast cancer (stage IIIB or IIIC) to evaluate the efficacy and safety, and to perform a subset analysis based on tumor biomarkers. Patients received 4mg/kg trastuzumab on day 1, followed by weekly treatments of 2mg/kg, in addition to 75mg/m 2 docetaxel...
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