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Cisplatin is an important drug in the treatment of childhood cancers. The aim of the present study was to define the pharmacokinetics of this agent in children. Cisplatin pharmacokinetics were studied in 22 patients following a 24-hr infusion of 50 - 120 mg/m 2 cisplatin. Total and free platinum (Pt) levels in plasma, and Pt in urine, were measured by atomic absorption spectrophotometry...
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