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Response to immune checkpoint blockade in mesenchymal tumors is poorly characterized, but immunogenomic dissection of these cancers could inform immunotherapy mediators. We identified a treatment-naive patient who has metastatic uterine leiomyosarcoma and has experienced complete tumor remission for >2 years on anti-PD-1 (pembrolizumab) monotherapy. We analyzed the primary tumor, the sole treatment-resistant...
Since there is significant increase in adoption of cloud computing, securing users emails is also a growing concern. This paper reviews the boundaries, privacy, vulnerabilities, varying legislations of cloud based emails, and how to mitigate such to provide reliable and secure cloud based email services for users and organizations. We propose a new framework to improve security of cloud based email...
Introduction Interleukin 2 (IL-2) induces an essential signal for T regulatory (Treg) cells. Without a functional IL-2R, only immature CD4+ Foxp3low CD25neg T cells develop, and these cells fail to suppress autoreactive T cells in the periphery. Discussion IL-2 functions during Treg cell development by upregulating Foxp3 and CD25 and by increasing the number of thymic Treg cells. Upon exiting the...
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