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Understanding the mechanism underlying multidrug resistance and identifying effective targets that can overcome it is of critical importance. In this study, mRNA and miRNA expression profiling of the drug resistant sublines, SGC7901/VCR and SGC7901/ADR, and their parental gastric cancer cell line SGC7901 were performed. A significant number of genes and a limited subset of miRNAs were commonly dysregulated,...
The development of Mechanical Micromanufacturing Technology-micromachine tools, as an alternative method for the fabrication of miniature products, is illustrated in this paper. Its advantages over MEMS and conventional large-scale ultraprecision machine tools is the ability to produce micro parts, composed of various of nonsilicon materials, with real 3D complex shapes or free-form surface, and meanwhile...
In this study we predict the frequency modulation atomic force microscopy (FM-AFM) subatomic frequency shift images of a Si (001) surface using empirical potential molecular dynamic methods. We model carbon single-wall nanotube caped tip and Si (001) surface to investigate the tip-surface interaction. The simulation shows that the FM-AFM imaging force mainly comes from C-Si/C-C chemical covalent bonding...
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