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The Na + /Ca 2+ -K + exchanger (NCKX) utilizes the inward Na + gradient and the outward K + gradient to promote Ca 2+ extrusion from cells. Here, we have characterized a second NCKX from Drosophila. Based on its chromosomal location (X chromosome) we have named it Ncxk-x. Three splice variants were isolated with three distinct N-terminal sequences...
Neural precursors often generate distinct cell types in a specific order, but the intrinsic or extrinsic cues regulating the timing of cell fate specification are poorly understood. Here we show that Drosophila neural precursors (neuroblasts) sequentially express the transcription factors Hunchback -> Kruppel -> Pdm -> Castor, with differentiated progeny maintaining the transcription factor...
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