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As apoE −/− and LDL-Receptor −/− mice are commonly used in atherosclerosis research; our objective was to point out the differences in HDL metabolism between mice and humans regarding the roles of apoE and LDLR.We examined HDL particles obtained from wild type (WT), LDLR −/− , and apoE −/− mice, as well as from normal, homozygous familial hypercholesterolemic (FH),...
Large-scale expansions of DNA repeats are implicated in numerous hereditary disorders in humans. We describe a yeast experimental system to analyze large-scale expansions of triplet GAA repeats responsible for the human disease Friedreich's ataxia. When GAA repeats were placed into an intron of the chimeric URA3 gene, their expansions caused gene inactivation, which was detected on the selective media...
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