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Focal brain cooling (FBC) is under investigation in preclinical trials of intractable epilepsy (IE), including status epilepticus (SE). This method has been studied in rodents as a possible treatment for epileptic disorders, but more evidence from large animal studies is required. To provide evidence that FBC is a safe and effective therapy for IE, we investigated if FBC using a titanium cooling plate...
ObjectiveRecently, focal brain cooling (FBC) was proposed as a method for treating refractory epilepsy. However, the precise influence of cooling on the molecular basis of epilepsy has not been elucidated. Thus the aim of this study was to assess the effect of FBC on glutamate (Glu) concentration, cerebral blood flow (CBF), and glucose metabolism in patients with intractable epilepsy.
MethodsNine...
The goal of the study was to investigate the effects of focal brain cooling on epileptic discharges (EDs) and background rhythms in the sensorimotor cortex of anesthetized rats using spectral analysis of electroencephalography (EEG).Penicillin G was administered intracortically into superficial layers of the left sensorimotor cortex and EDs were induced. Focal brain cooling was achieved using a cooling...
Purpose: Focal brain cooling is effective for suppression of epileptic seizures, but it is unclear if seizures can be suppressed without a substantial influence on normal neurologic function. To address the issue, a thermoelectrically driven cooling system was developed and applied in free‐moving rat models of focal seizure and epilepsy.
Methods: Focal seizures limited to the unilateral forelimb...
To investigate the effect of focal brain cooling on seizure, spectral analysis of electroencephalography (EEG) was performed in anesthetized rats intracortically injected with penicillin G potassium. Penicillin G induced epileptic discharges (EDs) and increased high frequency EEG bands. Use of a cooling device suppressed EDs with an effect that depended on the brain temperature. Fast Fourier Transform...
Focal cooling of the brain has the potential to terminate epileptic discharges. Therefore, in the present report, we review our past studies and discuss the future perspectives of brain cooling as a potential therapy for intractable epilepsy. The experiments were performed on Sprague-Dawley rats under halothane anesthesia. After craniotomy, the cooling device (Peltier chip) was placed on the cortical...
Focal brain cooling is under investigation in clinical trials of drug resistant epilepsy. This method has been studied intensively in rodents, but more evidence from large animal studies is required. To provide evidence that focal brain cooling is a safe and effective therapeutic intervention for intractable focal epilepsy, we investigated the placement of a newly-developed cooling device over the...
We propose a subdural electrode array guided by a 0.3mm-diameter shape memory alloy guidewire for a minimally-invasive method of electrocorticogram recording. The measured electric characteristics showed that the proposed electrodes are compatible with the application of electrocorticogram recording. Somatosensory evoked potential was measured by the proposed method in the animal test in vivo. The...
The realization of minimally invasive epilepsy surgery treatment, our goal, needs the accurate excision of the focus in a minimally invasive way. We think that one of the best ways to achieve this is cryosurgery. However, cryosurgery is not applied to epilepsy and the effect of cryosurgery on brain tissue is not well known. In this paper, we investigated the effects of freezing brain tissue on the...
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