Search results for: Kevin C.F. Fone

Items from 1 to 20 out of 21 results

article

Post-weaning social isolation of rats leads to long-term disruption of the gut microbiota-immune-brain axis

Fionn Dunphy Doherty, Siobhain M. O'Mahony, Veronica L. Peterson, Orla O'Sullivan, more

Brain, Behavior, and Immunity > 2018 > 68 > C > 261-273

Early-life stress is an established risk for the development of psychiatric disorders. Post-weaning isolation rearing of rats produces lasting developmental changes in behavior and brain function that may have translational pathophysiological relevance to alterations seen in schizophrenia, but the underlying mechanisms are unclear. Accumulating evidence supports the premise that gut microbiota influence...

article

The dopamine D3-preferring D2/D3 dopamine receptor partial agonist, cariprazine, reverses behavioural changes in a rat neurodevelopmental model for schizophrenia

David J.G. Watson, Madeleine V. King, Istvan Gyertyán, Béla Kiss, more

European Neuropsychopharmacology > 2016 > 26 > 2 > 208-224

Current antipsychotic medication is largely ineffective against the negative and cognitive symptoms of schizophrenia. One promising therapeutic development is to design new molecules that balance actions on dopamine D₂ and D₃ receptors to maximise benefits and limit adverse effects. This study used two rodent paradigms to investigate the action of the dopamine D₃-preferring D₃/D₂ receptor partial...

article

Dopamine D1 receptor stimulation modulates the formation and retrieval of novel object recognition memory: Role of the prelimbic cortex

Marie A. Pezze, Hayley J. Marshall, Kevin C.F. Fone, Helen J. Cassaday

European Neuropsychopharmacology > 2015 > 25 > 11 > 2145-2156

Previous studies have shown that dopamine D₁ receptor antagonists impair novel object recognition memory but the effects of dopamine D₁ receptor stimulation remain to be determined. This study investigated the effects of the selective dopamine D₁ receptor agonist SKF81297 on acquisition and retrieval in the novel object recognition task in male Wistar rats. SKF81297 (0.4 and 0.8mg/kg s.c.) given 15min...

article

Neonatal phencyclidine administration and post-weaning social isolation as a dual-hit model of ‘schizophrenia-like’ behaviour in the rat

Philip Lr Gaskin, Stephen Ph Alexander, Kevin Cf Fone

Psychopharmacology > 2014 > 231 > 12 > 2533-2545

Rationale Schizophrenia is a debilitating disorder comprising positive, negative and cognitive deficits with a poorly defined neurobiological aetiology; therefore, animal models with greater translational reliability are essential to develop improved therapies. Objectives This study combines two developmental challenges in rats, neonatal phencyclidine (PCP) injection and subsequent rearing in social...

article

Behavioural and neurochemical comparison of chronic intermittent cathinone, mephedrone and MDMA administration to the rat

Sinead E. Shortall, Alice E. Macerola, Rabbi T.R. Swaby, Rebecca Jayson, more

European Neuropsychopharmacology > 2013 > 23 > 9 > 1085-1095

The synthetic cathinone derivative, mephedrone, is a controlled substance across Europe. Its effects have been compared by users to 3,4-methylenedioxymethamphetamine (MDMA), but little data exist on its pharmacological properties. This study compared the behavioural and neurochemical effects of mephedrone with cathinone and MDMA in rats. Young-adult male Lister hooded rats received i.p. cathinone...

article

Exposure to maternal consumption of cafeteria diet during the lactation period programmes feeding behaviour in the rat

Thomas M. Wright, Kevin C.F. Fone, Simon C. Langley-Evans, Jörg-Peter W. Voigt

International Journal of Developmental Neuroscience > 2011 > 29 > 8 > 785-793

Lactational overfeeding programmes obesity in the adult rat, and also impacts on adult emotional behaviour. The present study investigated the impact of exposing the lactating female to a hypercaloric diet on structural aspects of feeding behaviour in the adult offspring as measured by the behavioural satiety sequence (BSS). Lactating Wistar rats were fed a hypercaloric cafeteria diet (CD) in addition...

article

Influence of social isolation in the rat on serotonergic function and memory – Relevance to models of schizophrenia and the role of 5-HT6 receptors

Charles A. Marsden, Madeleine V. King, Kevin C.F. Fone

Neuropharmacology > 2011 > 61 > 3 > 400-407

There is increasing awareness of the importance that early environmental factors have on brain development and their role in the neurobiology of neurodevelopmental disorders including schizophrenia. The isolation reared rat attempts to model adverse effects that human social isolation (absence of social contact) can have on normal brain development. The isolation reared rat also models aspects of...

article

THE MGLUR2/3 AGONIST LY379268 REVERSES POST-WEANING SOCIAL ISOLATION-INDUCED RECOGNITION MEMORY DEFICITS IN THE RAT

Caitlin A. Jones, Janice W. Smith, Angus M. Brown, Dorothee P. Auer, more

Schizophrenia Research > 2010 > 117 > 2-3 > 390

article

THE EFFECTS OF THE CANNABINOID CB2 RECEPTOR ANTAGONIST, AM630, ON ISOLATION REARING-INDUCED BEHAVIOURAL DEFICITS IN RATS

Asma Khan, David A. Kendall, Kevin C.F. Fone

Schizophrenia Research > 2010 > 117 > 2-3 > 391-392

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Behavioural characterisation of the effects of acute and repeated administration of GBR 12909 in rats: Further evaluation of a potential model of ADHD

Katherine N. Hewitt, Charles A. Marsden, Chris P. Hollis, Kevin C.F. Fone

Neuropharmacology > 2009 > 57 > 7-8 > 678-686

Attention deficit hyperactivity disorder (ADHD) is a common neuropsychiatric disorder characterised by excessive levels of hyperactivity, inattentiveness and impulsivity. Stimulant drugs which increase dopamine neurotransmission are treatments for ADHD. Hypodopaminergic fronto-striatal function with associated overactivity of the dopamine transporter (DAT) represents one possible neurobiological mechanism...

article

Mapping the central effects of methylphenidate in the rat using pharmacological MRI BOLD contrast

Neil Easton, Fiona H. Marshall, Charles A. Marsden, Kevin C.F. Fone

Neuropharmacology > 2009 > 57 > 7-8 > 653-664

Methylphenidate (Ritalin ^® ) is a selective dopamine reuptake inhibitor and an effective treatment for attention deficit hyperactivity disorder (ADHD) however the anatomical foci and neuronal circuits involved in these therapeutic benefits are unclear. This study determines the temporal pattern of brain regional activity change produced by systemic administration of a therapeutically relevant...

article

Chronic fluoxetine differentially modulates the hippocampal microtubular and serotonergic system in grouped and isolation reared rats

Massimiliano Bianchi, Kevin C.F. Fone, Ajit J. Shah, Alan R. Atkins, more

European Neuropsychopharmacology > 2009 > 19 > 11 > 778-790

Social isolation from weaning in rats produces behavioural and hippocampal structural changes at adulthood. Here, rats were group or isolation reared for eight-weeks. Following the initial four-week period of rearing, fluoxetine (10mg/kg i.p.) was administered for 28days. Changes in recognition memory, hippocampal monoamines, and cytoskeletal microtubules were investigated. Isolation-rearing for four-...

article

An update on the role of the 5-hydroxytryptamine6 receptor in cognitive function

Kevin C.F. Fone

Neuropharmacology > 2008 > 55 > 6 > 1015-1022

As the 5-hydroxytryptamine ₆ (5-HT ₆ ) receptor is almost exclusively expressed in the CNS, particularly in areas associated with learning and memory, many studies have examined its role in cognitive function in the rodent, as reviewed herein. Most studies, in healthy adult rats, report that 5-HT ₆ receptor antagonists enhance retention of spatial learning in the Morris water...

article

A role for the 5-HT1A, 5-HT4 and 5-HT6 receptors in learning and memory

Madeleine V. King, Charles A. Marsden, Kevin C.F. Fone

Trends in Pharmacological Sciences > 2008 > 29 > 9 > 482-492

The serotonergic system is implicated in the neurobiological control of learning and memory, both in healthy individuals and pathological disorders, although the underlying mechanisms remain elusive. After the cloning and characterization of serotonin, or 5-hydroxytryptamine (5-HT), receptors and the resultant development of selective agonist and antagonist compounds and transgenic receptor-knockout...

article

Behavioural and neurochemical effects of post-weaning social isolation in rodents—Relevance to developmental neuropsychiatric disorders

Kevin C.F. Fone, M. Veronica Porkess

Neuroscience and Biobehavioral Reviews > 2008 > 32 > 6 > 1087-1102

Exposing mammals to early-life adverse events, including maternal separation or social isolation, profoundly affects brain development and adult behaviour and may contribute to the occurrence of psychiatric disorders, such as depression and schizophrenia in genetically predisposed humans. The molecular mechanisms underlying these environmentally induced developmental adaptations are unclear and best...

article

The effects of pharmacological blockade of the 5-HT6 receptor on formalin-evoked nociceptive behaviour, locomotor activity and hypothalamo–pituitary–adrenal axis activity in rats

David P. Finn, Kevin C.F. Fone, Simon R.G. Beckett, Jonathan A. Baxter, more

European Journal of Pharmacology > 2007 > 569 > 1-2 > 59-63

5-hydroxytryptamine (5-HT) mediates behavioural and neuroendocrine responses to noxious or stressful stimuli. 5-HT ₆ receptors are expressed in brain regions involved in nociceptive processing, however, their role in nociception is unknown. Here we demonstrate that acute, systemic administration of the 5-HT ₆ receptor antagonist, 5-chloro-N-(4-methoxy-3-benzothio-phenesulfonamide (SB-271046),...

article

Long-lasting changes in behavioural and neuroendocrine indices in the rat following neonatal maternal separation: Gender-dependent effects

Helge A. Slotten, Mikhail Kalinichev, Jim J. Hagan, Charles A. Marsden, more

Brain Research > 2006 > 1097 > 1 > 123-132

Neonatal maternal separation (MS) has been used to model long-term changes in neurochemistry and behaviour associated with exposure to early-life stress. This study characterises changes in behavioural and neuroendocrine parameters following MS. On postnatal days (PND) 3–15, male and female Long–Evans rats underwent 3 h daily MS. Non-handled (NH) control offspring remained with the dams. Starting...

article

Stimulants: use and abuse in the treatment of attention deficit hyperactivity disorder

Kevin CF Fone, David J Nutt

Current Opinion in Pharmacology > 2005 > 5 > 1 > 87-93

Attention deficit hyperactivity disorder (ADHD) is the most prevalent childhood developmental disorder and is also of unclear neurobiological aetiology. However, recent advances in molecular genetics and brain imaging implicate dopaminergic hypofunction in the frontal lobes and basal ganglia in ADHD. Psychostimulants (e.g. methylphenidate and amphetamine, which are potent inhibitors of the dopamine...

article

Decreased social behaviour following 3,4-methylenedioxymethamphetamine (MDMA) is accompanied by changes in 5-HT ₂ _A receptor responsivity

Eleanor J. Bull, Peter H. Hutson, Kevin C.F. Fone

Neuropharmacology > 2004 > 46 > 2 > 202-210

This study examined the involvement of the 5-HT ₂ _A receptor in the long-term anxiogenic effect of a brief exposure of young rats to 3,4-methylenedioxymethamphetamine (MDMA) using the social interaction and elevated plus-maze paradigms. Wistar rats (post-natal day (PND) 28) received either MDMA (5 mg/kg i.p.) or saline (1 ml/kg i.p.) hourly for 4 h on 2 consecutive days. Locomotor activity...

article

DR4004, a putative 5-HT ₇ receptor antagonist, also has functional activity at the dopamine D2 receptor

Helen A. Kogan, Charles A. Marsden, Kevin C.F. Fone

European Journal of Pharmacology > 2002 > 449 > 1-2 > 105-111

The tetrahydrobenzindole, 2a-(4-(4-phenyl-1,2,3,6-tetrahydropyridyl)butyl)-2a,3,4,5-tetrahydrobenzo[cd ]indol-2(1H)-one (DR4004) has been described as a highly selective antagonist for the 5-hydroxytryptamine ₇ (5-HT ₇ ) receptor [J. Med. Chem. 42 (1999) 533]. Consistent with original data, DR4004 bound to rat hypothalamic membranes with an affinity of 7.3+/-0.2 (pK _i +/-S...

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Search results for: Kevin C.F. Fone

Post-weaning social isolation of rats leads to long-term disruption of the gut microbiota-immune-brain axis

The dopamine D3-preferring D2/D3 dopamine receptor partial agonist, cariprazine, reverses behavioural changes in a rat neurodevelopmental model for schizophrenia

Dopamine D1 receptor stimulation modulates the formation and retrieval of novel object recognition memory: Role of the prelimbic cortex

Neonatal phencyclidine administration and post-weaning social isolation as a dual-hit model of ‘schizophrenia-like’ behaviour in the rat

Behavioural and neurochemical comparison of chronic intermittent cathinone, mephedrone and MDMA administration to the rat

Exposure to maternal consumption of cafeteria diet during the lactation period programmes feeding behaviour in the rat

Influence of social isolation in the rat on serotonergic function and memory – Relevance to models of schizophrenia and the role of 5-HT6 receptors

THE MGLUR2/3 AGONIST LY379268 REVERSES POST-WEANING SOCIAL ISOLATION-INDUCED RECOGNITION MEMORY DEFICITS IN THE RAT

THE EFFECTS OF THE CANNABINOID CB2 RECEPTOR ANTAGONIST, AM630, ON ISOLATION REARING-INDUCED BEHAVIOURAL DEFICITS IN RATS

Behavioural characterisation of the effects of acute and repeated administration of GBR 12909 in rats: Further evaluation of a potential model of ADHD

Mapping the central effects of methylphenidate in the rat using pharmacological MRI BOLD contrast

Chronic fluoxetine differentially modulates the hippocampal microtubular and serotonergic system in grouped and isolation reared rats

An update on the role of the 5-hydroxytryptamine6 receptor in cognitive function

A role for the 5-HT1A, 5-HT4 and 5-HT6 receptors in learning and memory

Behavioural and neurochemical effects of post-weaning social isolation in rodents—Relevance to developmental neuropsychiatric disorders

The effects of pharmacological blockade of the 5-HT6 receptor on formalin-evoked nociceptive behaviour, locomotor activity and hypothalamo–pituitary–adrenal axis activity in rats

Long-lasting changes in behavioural and neuroendocrine indices in the rat following neonatal maternal separation: Gender-dependent effects

Stimulants: use and abuse in the treatment of attention deficit hyperactivity disorder

Decreased social behaviour following 3,4-methylenedioxymethamphetamine (MDMA) is accompanied by changes in 5-HT ₂ _A receptor responsivity

DR4004, a putative 5-HT ₇ receptor antagonist, also has functional activity at the dopamine D2 receptor

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