Search results for: Su-Shu Pan

Items from 1 to 6 out of 6 results

article

Crystal Structure of Human Glutathione S -Transferase A3-3 and Mechanistic Implications for Its High Steroid Isomerase Activity ^† ^, ^‡

Yijun Gu, Jianxia Guo, Ajay Pal, Su-Shu Pan, more

Biochemistry > 2004 > 43 > 50 > 15673 - 15679

article

Use of high-performance liquid chromatography to characterize the rapid decomposition of wortmannin in tissue culture media

Julianne L. Holleran, Merrill J. Egorin, Eleanor G. Zuhowski, Robert A. Parise, more

Analytical Biochemistry > 2003 > 323 > 1 > 19-25

Although wortmannin is extensively used in molecular signaling studies, its stability in tissue culture medium has not been assessed precisely. Therefore, we used high-performance liquid chromatography (HPLC) and mass spectrometry (MS) to characterize the decomposition of wortmannin in five commonly used media. Wortmannin was added to medium alone or to medium supplemented with 10% unheated or heat-inactivated...

article

C-Terminal Region Amino Acid Substitutions Contribute to Catalytic Differences between Murine Class Alpha Glutathione Transferases mGSTA1-1 and mGSTA2-2 toward anti- Diol Epoxide Isomers of Benzo[ c ]phenanthrene ^†

Ajai Pal, Yijun Gu, Su-Shu Pan, Xinhua Ji, more

Biochemistry > 2001 > 40 > 24 > 7047 - 7053

article

Two Distinct 4-Hydroxynonenal Metabolizing Glutathione S-Transferase Isozymes Are Differentially Expressed in Human Tissues

Ji-Zhong Cheng, Yusong Yang, Sharda P. Singh, Sharad S. Singhal, more

Biochemical and Biophysical Research Communications > 2001 > 282 > 5 > 1268-1274

The two previously reported human glutathione S-transferase isozymes, hGST5.8 and hGSTA4-4, have been suggested to be similar because of their comparable activities toward 4-hydroxynonenal-GSH conjugation. Here, we demonstrate that hGST5.8 and hGSTA4-4 are distinct. Antibodies raised against hGSTA4-4 did not recognize hGST5.8, and antibodies raised against mouse GSTA4-4 that cross-react with hGST5...

article

Cloning, Expression, and Biochemical Characterization of a Functionally Novel Alpha Class GlutathioneS-Transferase with Exceptional Activity in the Glutathione Conjugation of (+)-Anti-7,8-dihydroxy-9,10-oxy-7,8,9,10-tetrahydrobenzo(a)pyrene

Hong Xia, Su-Shu Pan, Xun Hu, Sanjay K. Srivastava, more

Archives of Biochemistry and Biophysics > 1998 > 353 > 2 > 337-348

The present study describes cDNA cloning, expression, and kinetic characterization of the two subunits of a murine alpha-class glutathione (GSH)S-transferase (GST) isoenzyme (previously designated as GST 9.5), which, unlike other alpha-class mammalian GSTs, is exceptionally efficient in the GSH conjugation of(+)-anti-7,8-dihydroxy-9,10-oxy-7,8,9,10-tetrahydrobenzo-(a)pyrene [(+)-anti-BPDE] [X. Hu,...

article

Differential Induction of NAD(P)H:Quinone Oxidoreductase by Anti-Carcinogenic Organosulfides from Garlic

Shivendra V. Singh, Su Shu Pan, Sanjay K. Srivastava, Hong Xia, more

Biochemical and Biophysical Research Communications > 1998 > 244 > 3 > 917-920

This study was undertaken to elucidate the mechanism of organ specificity and differential efficacy of garlic organosulfides (OSCs) [diallyl sulfide (DAS), diallyl disulfide (DADS), diallyl trisulfide (DATS), dipropyl sulfide (DPS) and dipropyl disulfide (DPDS)] in preventing benzo(a)pyrene (BP)-induced tumorigenesis in mice. The results of the present study reveal a good correlation between chemopreventive...

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Keywords

4-HYDROXYNONENAL (1)
BENZO(A)PYRENE; CARCINOGENESIS; GLUTATHIONES-TRANSFERASE; DETOXIFICATION (1)
GLUTATHIONE (1)
HPLC (1)
HUMAN GLUTATHIONE S-TRANSFERASE (1)
PI-3 KINASE (1)
WORTMANNIN (1)

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Elsevier (4)
ACS (2)

INFONA - science communication portal

Search results for: Su-Shu Pan

Crystal Structure of Human Glutathione S -Transferase A3-3 and Mechanistic Implications for Its High Steroid Isomerase Activity ^† ^, ^‡

Use of high-performance liquid chromatography to characterize the rapid decomposition of wortmannin in tissue culture media

C-Terminal Region Amino Acid Substitutions Contribute to Catalytic Differences between Murine Class Alpha Glutathione Transferases mGSTA1-1 and mGSTA2-2 toward anti- Diol Epoxide Isomers of Benzo[ c ]phenanthrene ^†

Two Distinct 4-Hydroxynonenal Metabolizing Glutathione S-Transferase Isozymes Are Differentially Expressed in Human Tissues

Cloning, Expression, and Biochemical Characterization of a Functionally Novel Alpha Class GlutathioneS-Transferase with Exceptional Activity in the Glutathione Conjugation of (+)-Anti-7,8-dihydroxy-9,10-oxy-7,8,9,10-tetrahydrobenzo(a)pyrene

Differential Induction of NAD(P)H:Quinone Oxidoreductase by Anti-Carcinogenic Organosulfides from Garlic

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INFONA - science communication portal

Search results for: Su-Shu Pan

Crystal Structure of Human Glutathione S -Transferase A3-3 and Mechanistic Implications for Its High Steroid Isomerase Activity † , ‡

Use of high-performance liquid chromatography to characterize the rapid decomposition of wortmannin in tissue culture media

C-Terminal Region Amino Acid Substitutions Contribute to Catalytic Differences between Murine Class Alpha Glutathione Transferases mGSTA1-1 and mGSTA2-2 toward anti- Diol Epoxide Isomers of Benzo[ c ]phenanthrene †

Two Distinct 4-Hydroxynonenal Metabolizing Glutathione S-Transferase Isozymes Are Differentially Expressed in Human Tissues

Cloning, Expression, and Biochemical Characterization of a Functionally Novel Alpha Class GlutathioneS-Transferase with Exceptional Activity in the Glutathione Conjugation of (+)-Anti-7,8-dihydroxy-9,10-oxy-7,8,9,10-tetrahydrobenzo(a)pyrene

Differential Induction of NAD(P)H:Quinone Oxidoreductase by Anti-Carcinogenic Organosulfides from Garlic

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Crystal Structure of Human Glutathione S -Transferase A3-3 and Mechanistic Implications for Its High Steroid Isomerase Activity ^† ^, ^‡

C-Terminal Region Amino Acid Substitutions Contribute to Catalytic Differences between Murine Class Alpha Glutathione Transferases mGSTA1-1 and mGSTA2-2 toward anti- Diol Epoxide Isomers of Benzo[ c ]phenanthrene ^†