Search results for: Alina Ostrowska

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article

Does soft really matter? Differentiation of induced pluripotent stem cells into mesenchymal stromal cells is not influenced by soft hydrogels

Roman Goetzke, Julia Franzen, Alina Ostrowska, Michael Vogt, more

Biomaterials > 2018 > 156 > C > 147-158

Induced pluripotent stem cells (iPSCs) can be differentiated toward mesenchymal stromal cells (MSCs), but this transition remains incomplete. It has been suggested that matrix elasticity directs cell-fate decisions. Therefore, we followed the hypothesis that differentiation of primary MSCs and generation of iPSC-derived MSCs (iMSCs) is supported by a soft matrix of human platelet lysate (hPL-gel)...

article

Benzylpenicillin, acetylcysteine and silibinin as antidotes in human hepatocytes intoxicated with α-amanitin

Jan Magdalan, Alina Ostrowska, Aleksandra Piotrowska, Agnieszka Gomułkiewicz, more

Experimental and Toxicologic Pathology > 2010 > 62 > 4 > 367-373

Fatalities due to mushroom poisonings are increasing worldwide, with high mortality rate resulting from ingestion of amanitin-producing species. Intoxications caused by amanitin-containing mushrooms represent an unresolved problem in clinical toxicology since no specific and fully efficient antidote is available. The objective of this study was a comparative evaluation of benzylpenicillin (BPCN),...

article

Comparative antidotal efficacy of benzylpenicillin, ceftazidime and rifamycin in cultured human hepatocytes intoxicated with α-amanitin

Jan Magdalan, Alina Ostrowska, Aleksandra Piotrowska, Agnieszka Gomułkiewicz, more

Archives of Toxicology > 2009 > 83 > 12 > 1091-1096

The most often used antidote to treat poisoning caused by amanitin-containing mushrooms is benzylpenicillin (BPCN). However, a very few reports suggest that other antibiotics such as ceftazidime (CEFT) and rifamycin SV (RIFSV) show better antidote activity against amanitins than BPCN. Given this, there is an ongoing debate as which of three antidotes is optimal for treatment of such poisonings. In...

article

Hypothermic storage of isolated human hepatocytes: a comparison between University of Wisconsin solution and a hypothermosol platform

Alina Ostrowska, Kenan Gu, Donald C. Bode, Robert G. Buskirk

Archives of Toxicology > 2009 > 83 > 5 > 493-502

Until now little is known about the functional integrity of human hepatocytes after hypothermic storage. In order to address this limitation, we evaluated several commercially available hypothermic preservation media for their abilities to protect freshly isolated hepatocytes during prolonged cold storage. Human hepatocytes were isolated from non-transplantable/rejected donor livers and resuspended...

article

Early morphological and functional alterations in canine hepatocytes due to α-amanitin, a major toxin of Amanita phalloides

Jan Magdalan, Alina Ostrowska, Marzena Podhorska-Okołów, Aleksandra Piotrowska, more

Archives of Toxicology > 2009 > 83 > 1 > 55-60

The toadstool death cap (Amanita phalloides) and its subspecies, destroying angel (A. virosa) and death angel (A. verna) are responsible for nearly 95% of all fatal mushroom poisonings. High mortality rate in A. phalloides intoxications is principally a result of the acute liver failure following significant hepatocyte damage due to hepatocellular uptake of amanitins, the major toxins of this mushroom...

article

165. Extended hypothermic storage of isolated human hepatocytes utilizing HypoThermosol-FRS

Aby Mathew, John M. Baust, Alina Ostrowska, Robert G. Van Buskirk, more

Cryobiology > 2006 > 53 > 3 > 437

article

Hepatocyte transplantation in acute liver failure

Bahri M. Bilir, Denis Guinette, Fritz Karrer, David A. Kumpe, more

Liver Transplantation > 2000 > 6 > 1 > 32-40

The majority of patients with acute liver failure (ALF) die waiting for orthotopic liver transplantation (OLT). No other treatment modality is shown to improve survival. This study was conducted to assess the safety and feasibility of hepatocyte transplantation (HT) and subsequent engrafanent and function of donor cells. Functional and structural integrity of cryopreserved and thawed human hepatocytes...

article

Investigation of Functional and Morphological Integrity of Freshly Isolated and Cryopreserved Human Hepatocytes

Alina Ostrowska, Donald C. Bode, Jennifer Pruss, Bahri Bilir, more

Cell and Tissue Banking > 2000 > 1 > 1 > 55-68

There is a pressing need for alternative therapeutic methods effective in the treatment of patients with liver insufficiency. Isolated human hepatocytes may be a viable alternative or adjunct to orthotopic liver transplantation in such patients. The purpose of this study was to evaluate the viability and functional integrity of freshly isolated and cryopreserved human hepatocytes, in preparation for...

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Autoimmune Destruction of Islet Grafts in the NOD Mouse Is Resistant to 15-Deoxyspergualin but Sensitive to Anti-CD4 Antibody

Mark D. Stegall, Zeev Loberman, Alina Ostrowska, Marylin Coulombe, more

Journal of Surgical Research > 1996 > 64 > 2 > 156-160

Islet allografts transplanted into Type I diabetic recipients may be destroyed by allorejection or recurrent autoimmune diabetes. We studied islet transplantation in three murine models in order to determine the relative sensitivity of autoimmunity and alloimmunity to two immunosuppressive agents that may be useful in clinical islet transplantation: 15-deoxyspergualin (DSG) and anti-CD4 antibody (GK...

article

Prolongation of islet allograft survival with an antibody to vascular cell adhesion molecule 1

Mark D. Stegall, Alina Ostrowska, James Haynes, Frederick Karrer, more

Surgery > 1995 > 118 > 2 > 366-370

Background. The purpose of this study was to determine whether an antibody to vascular cell adhesion molecule 1 (VCAM1) prolongs the survival of neovascularized pancreatic islet allografts.Methods. We treated CBA (H-2 ^k ) recipients of BALB/c (H-2 ^d ) islet allografts with anti-VCAM1 antibody (400 μg/day for 20 days). Sensitized recipients of islet grafts also were treated with anti-VCAM1...

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Search results for: Alina Ostrowska

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