Search results for: Kyohei Otani

Items from 1 to 13 out of 13 results

article

Medical comorbidities leading to hypernatremia during COVID‐19 pandemic in patients with mood disorders on long‐term lithium therapy

Kyohei Otani, Kaori Mogi, Atsumi Miura, Hiroyuki Miyai, more

Bipolar Disorders > 24 > 7 > 770 - 773

article

Characteristics of COVID‐19 delirium intervened by a psychiatric liaison team in the first 2 years of the COVID‐19 pandemic in Japan

Kyohei Otani, Atsumi Miura, Hiroyuki Miyai, Haruko Fukushima, more

Psychiatry and Clinical Neurosciences > 76 > 11 > 599 - 600

article

Auger electron spectroscopic analysis of corrosion products formed on A3003 aluminum alloy in model fresh water with different Zn²⁺ concentration

Kyohei Otani, Md. Saiful Islam, Masatoshi Sakairi, Akira Kaneko

Surface and Interface Analysis > 51 > 12 > 1207 - 1213

The corrosion morphology and composition of corrosion products of A3003 formed in model fresh water with different Zn²⁺ concentrations were investigated by immersion tests combined with surface observations and analysis using an Auger electron spectroscope (AES). The cross‐sectional AES observations showed that the thickness of the corrosion product layer formed on A3003 decreases with increases in...

article

Corrosion inhibition effects of metal cations on SUS304 in 0.5 M Cl− aqueous solution

Md. Saiful Islam, Kyohei Otani, Masatoshi Sakairi

Corrosion Science > 2018 > 140 > C > 8-17

The corrosion characteristics of SUS304 exposed to 0.5 M Cl⁻ aqueous solution containing different metal cations were studied with immersion tests, surface analysis and electrochemical tests. The mechanism of corrosion with metal cations was clarified by the XPS analysis results together with the hard and soft acid and base (HSAB) concept and the passive films structure. It is supposed that metal...

article

Effects of metal cations on mild steel corrosion in 10mM Cl− aqueous solution

Md. Saiful Islam, Kyohei Otani, Masatoshi Sakairi

Corrosion Science > 2018 > 131 > C > 17-27

The influences of metal cations on the corrosion of mild steel in 10mM Cl⁻ aqueous solutions were investigated by electrochemical techniques and immersion tests. Immersion tests and electrochemical impedance spectroscopy (EIS) results showed that Zn²⁺ has a significant effect on corrosion inhibition. Surface morphological inspection also showed the smooth surface of specimen immersed in Zn²⁺ containing...

article

Effects of metal cations on corrosion of mild steel in model fresh water

Kyohei Otani, Masatoshi Sakairi

Corrosion Science > 2016 > 111 > C > 302-312

The effects of metal cations on corrosion of mild steel in model fresh water were investigated by electrochemical techniques and immersion tests. Analysis of X-ray photoelectron spectroscopy showed that metal cations have large hardness of cations, X, are incorporated in passive films. The electrochemical and immersion results showed that X is not suitable as a corrosion indicator of mild steel. A...

article

Association study of gender identity disorder and sex hormone-related genes

Hiroshi Ujike, Kyohei Otani, Mikiya Nakatsuka, Kazushi Ishii, more

Progress in Neuropsychopharmacology & Biological Psychiatry > 2009 > 33 > 7 > 1241-1244

To investigate the biological mechanism of gender identity disorder (GID), five candidate sex hormone-related genes, encoding androgen receptor (AR), estrogen receptors α (ERα) and β (ERβ), aromatase (CYP19), and progesterone receptor (PGR) were analyzed by a case–control association study. Subjects were 242 transsexuals (74 male-to-female patients (MTF) and 168 female-to-male patients (FTM)), and...

article

Reduced CYP2D6 activity is a negative risk factor for methamphetamine dependence

Kyohei Otani, Hiroshi Ujike, Ayumu Sakai, Yuko Okahisa, more

Neuroscience Letters > 2008 > 434 > 1 > 88-92

Because methamphetamine (METH) is metabolized by CYP2D6 at the first step of hydroxylation and demethylation, it is possible that functional variants of CYP2D6 alter susceptibility to methamphetamine-induced dependence. We genotyped CYP2D6*1, *4, *5, *10, and *14 for 202 patients with METH dependence and 337 controls in a Japanese population and found a significant association of the CYP2D6 gene with...

article

A Genetic Variant of the Serine Racemase Gene Is Associated with Schizophrenia

Yukitaka Morita, Hiroshi Ujike, Yuji Tanaka, Kyohei Otani, more

Biological Psychiatry > 2007 > 61 > 10 > 1200-1203

Serine racemase (SRR) is a brain-enriched enzyme that converts l-serine to d-serine, which acts as an endogenous ligand of N-methyl d-aspartate (NMDA) receptors. Dysfunction of SRR may reduce the function of NMDA receptors and susceptibility to schizophrenia.We genotyped three single-nucleotide polymorphisms (SNPs) of the 5′ region of the SRR gene in 525 patients with schizophrenia and 524 healthy...

article

Genetic variant of prodynorphin gene is risk factor for methamphetamine dependence

Akira Nomura, Hiroshi Ujike, Yuji Tanaka, Kyohei Otani, more

Neuroscience Letters > 2006 > 400 > 1-2 > 158-162

Previous studies have indicated that genetic factors substantially affect development of substance use disorders, including methamphetamine dependence. Prodynorphin (PDYN) is an opioid peptide precursor that yields dynorphins, endogenous κ opioid-receptor agonists that play important roles in substance abuse. A physiologically active polymorphism of 1–4 repeats of a 68-bp element in the promoter region...

article

The ZDHHC8 gene did not associate with bipolar disorder or schizophrenia

Kyohei Otani, Hiroshi Ujike, Yuji Tanaka, Yukitaka Morita, more

Neuroscience Letters > 2005 > 390 > 3 > 166-170

The zinc finger and DHHC domain-containing protein 8 (ZDHHC8) gene is located on chromosome 22q11, which several genome scans have provided repeated evidence for a significant linkage with bipolar disorder (BPD) and schizophrenia. A recent study revealed that a single nucleotide polymorphism (SNP), rs175174, which has potential effects on splicing, in intron 4 of the ZDHHC8 gene is associated with...

article

The X-box binding protein 1 (XBP1) gene is not associated with methamphetamine dependence

Yukitaka Morita, Hiroshi Ujike, Yuji Tanaka, Naohiko Uchida, more

Neuroscience Letters > 2005 > 383 > 1-2 > 194-198

Bipolar disorder has known as a high risk factor for substance abuse and dependence such as alcohol and illegal drugs. Recently, Kakiuchi et al. reported that the −116C/G polymorphism in the promoter region of the X-box binding protein 1 (XBP-1) gene, which translates a transcription factor specific for endoplasmic reticulum stress caused by misfolded proteins, was associated with bipolar disorders...

article

The GABA type A receptor α5 subunit gene is associated with bipolar I disorder

Kyohei Otani, Hiroshi Ujike, Yuji Tanaka, Yukitaka Morita, more

Neuroscience Letters > 2005 > 381 > 1-2 > 108-113

Several genetic studies have revealed that bipolar disorders are linked with the chromosomal locus of 15q11–q13, where the γ-aminobutyric acid (GABA) receptor α5 subunit gene (GABRA5) locates. GABA is one of the major neurotransmitters that may be involved in the pathogenesis of bipolar disorder. Five polymorphisms in the GABRA5 gene, −754C>T in the promoter region, IVS1-21G>A, IVS2-26T>A,...

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