Search results for: L. Vishwakarma

Items from 1 to 10 out of 10 results

article

In vivo effective dibenzo[b,d]furan-1-yl-thiazoles as novel PDE-4 inhibitors

Gopalan Balasubramanian, Sukunath Narayanan, Lavanya Andiappan, Thirunavukkarasu Sappanimuthu, more

Bioorganic & Medicinal Chemistry > 2016 > 24 > 22 > 5702-5716

Herein we report the synthesis, PDE-4B and TNF-α inhibitory activities of a few dibenzo[b,d]furan-1-yl-thiazole derivatives. The hydroxycyclohexanol amide derivatives 14, 18, 24, 29, 31 and 33 exhibited promising in vitro PDE-4B and TNF-α inhibitory activities. Compound 24 showed good systemic availability in preclinical animal models and was also found to be non-toxic (exploratory mutagenicity test)...

article

Structural, morphological and electroluminescence studies of Zno:Co nanophosphor

Anju Singh, H. L. Vishwakarma

Applied Physics A > 2016 > 122 > 9 > 1-11

The nanoparticles of zinc oxide (ZnO) doped with various concentrations of cobalt (Co) were synthesized by chemical precipitation method in the presence of capping agent polyvinylpyrrolidone (PVP). The effect of doping concentration on structural and morphological properties has been studied by X-ray diffraction (XRD) and scanning electron microscope (SEM). Cell volume, bond length, texture coefficient,...

article

Mitochondrial membrane potential (MMP) regulates sperm motility

Saurabh Kumar Agnihotri, Ankit Kumar Agrawal, Bilal Ahmad Hakim, A. L. Vishwakarma, more

In Vitro Cellular & Developmental Biology - Animal > 2016 > 52 > 9 > 953-960

Sperm motility is the major decisive factor in determining male fertility. The objective of the present study was to analyse the effect of mitochondrial membrane potential (MMP) on the temporal regulation of sperm motility. Observations were recorded in various rodent species and among differentially motile sperm fractions including swim up and leftover layer of human semen sample using JC-1 stain...

chapter

Metropolitan water tank pollution monitoring and purification using PID control

Ninad D. Mehendale, O. A. Sharma, S. A. Shah, S. L. Vishwakarma

2016 International Conference on Communication and Signal Processing (ICCSP) > 212 - 214

2016 International Conference on Communication and Signal Processing (ICCSP)

Normal water contains particulate matter including suspended particles, parasites, bacteria, algae, viruses, fungi and a range of dissolved and particulate material derived from the surfaces, that water may have made contact with after falling as rain. This contaminates water for household and drinking purposes. Utilization of such water has a potential to cause water borne diseases like, cholera...

article

Role of preoptic area thermo TRPV1 channel in sleep and thermoregulation

R. Yadav, L. Vishwakarma, H. Mallick

Sleep Medicine > 2015 > 16 > Supplement 1 > S68

article

Ovariectomized Rats with Established Osteopenia have Diminished Mesenchymal Stem Cells in the Bone Marrow and Impaired Homing, Osteoinduction and Bone Regeneration at the Fracture Site

Deepshikha Tewari, Mohd Parvez Khan, Nitin Sagar, Shyamsundar P. China, more

Stem Cell Reviews and Reports > 2015 > 11 > 2 > 309-321

We investigated deleterious changes that take place in mesenchymal stem cells (MSC) and its fracture healing competence in ovariectomy (Ovx)-induced osteopenia. MSC from bone marrow (BM) of ovary intact (control) and Ovx rats was isolated. ^99m Tc-HMPAO (Technitium hexamethylpropylene amine oxime) labeled MSC was systemically transplanted to rats and fracture tropism assessed by...

article

Topical atorvastatin ameliorates 12-O-tetradecanoylphorbol-13-acetate induced skin inflammation by reducing cutaneous cytokine levels and NF-κB activation

Nagaraj M. Kulkarni, Milind M. Muley, Mallikarjun S. Jaji, G. Vijaykanth, more

Archives of Pharmacal Research > 2015 > 38 > 6 > 1238-1247

Atorvastatin is a 3-hydroxy-3-methylglutaryl coenzyme-A reductase inhibitor used in the treatment of atherosclerosis and dyslipidemia. Studies have evaluated the utility of statins in the treatment of skin inflammation but with varied results. In the present study, we investigated the effect of atorvastatin on TNF-α release and keratinocyte proliferation in vitro and in acute and chronic 12-O-tetradecanoylphorbol-13-acetate...

article

Study of structural, morphological, optical and electroluminescent properties of undoped ZnO nanorods grown by a simple chemical precipitation

A. Singh, H. L. Vishwakarma

Materials Science Poland > 2015 > Vol. 33, No. 4 > 751--759

In this work, zinc oxide (ZnO) nanorods were obtained by a simple chemical precipitation method in the presence of capping agent: polyvinyl pyrrolidone (PVP) at room temperature. X-ray diffraction (XRD) result indicates that the synthesized undoped ZnO nanorods have hexagonal wurtzite structure without any impurities. It has been observed that the growth direction of the prepared ZnO nanorods is [1...

article

Modulation of the cyclooxygenase pathway via inhibition of nitric oxide production contributes to the anti-inflammatory activity of kaempferol

Mahamad Yunnus A. Mahat, Nagaraj M. Kulkarni, Santosh L. Vishwakarma, Farhin R. Khan, more

European Journal of Pharmacology > 2010 > 642 > 1-3 > 169-176

Kaempferol has been reported to inhibit nitric oxide synthase and cyclooxygenase enzymes in animal models. The present study was designed to investigate whether kaempferol modulates the cyclooxygenase pathway via inhibition of nitric oxide production, which in turn contributes to its anti-inflammatory activity. Investigations were performed using carrageenan induced rat air pouch model. Inflammation...

article

Amelioration of STZ-induced type 1 diabetic nephropathy by aqueous extract of Enicostemma littorale Blume and swertiamarin in rats

Rakesh D. Sonawane, Santosh L. Vishwakarma, S. Lakshmi, Mandapati Rajani, more

Molecular and Cellular Biochemistry > 2010 > 340 > 1-2 > 1-6

Diabetic nephropathy (DN) is one of the foremost causes of renal failure and a primary cause of diabetes mellitus related death. Previously, we have reported that aqueous extract of Enicostemma littorale has potential antidiabetic activity. In the present study, we have investigated the effect of aqueous extract of E. littorale 1 g/kg, p.o. and swertiamarin 50 mg/kg, p.o. daily for 3 weeks in type...

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Search results for: L. Vishwakarma

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