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Microglia play crucial roles in increased inflammation in the central nervous system upon brain injuries and diseases. Extracellular ADP has been reported to induce microglia chemotaxis and membrane ruffle formation through P2Y12 receptor. In this study, we examined the role of ERK1/2 activation in ADP‐induced microglia chemotaxis. ADP stimulation increases the phosphorylation of extracellular signal‐regulated...
Microglia are immune effector cells in the central nervous system (CNS) and their activation, migration and proliferation play crucial roles in brain injuries and diseases. We examined the role of intracellular Ca2+‐independent phospholipase A2 (iPLA2) in the regulation of microglia chemotaxis toward ADP. Inhibition of iPLA2 by 4‐bromoenol lactone (BEL) or iPLA2 knockdown exerted a significant inhibition...
Double-stranded RNA (dsRNA) has been implicated as a potential immune stimulant in activating microglia, which can cause chronic neurodegeneration. In this study, we examined the involvement of different types of mitogen-activated protein kinases (MAPKs) in the induction of inducible nitric oxide synthase (iNOS) by dsRNA in microglial cells. Nitric oxide production was increased after exposure of...
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