Monoclonal (MoAB) anti-N and anti-M were tested against normal, T-activated, and Tn-activated RBCs. In vivo T and Tn activation affects the sialic acid expression on the RBCs which may affect the binding of antibodies to the M and / or N antigens. The majority of MoAB anti-M and anti-N in this workshop demonstrated some effect from in vivo T and Tn activation.
Monoclonal antibodies from the 2D3 Section (Other Non-specific Erythrocyte Antigens) of the Third International Workshop & Symposium on Monoclonal Antibodies Against Human Red Blood Cell and Related Antigens were tested using standard serological tube methods. Each antibody was tested to determine the presence of prozoning. A selected panel of red blood cells was tested against each antibody at...
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