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During the last few years it was reported, that many selective ligands of 5-HT 1A receptors - structural buspirone analogs - display an anxiolytic activity (gepirone, ipsapirone, lesopitron and others). The pharmacological profile of those drugs differs from buspirone, but there are all selective partial antagonists of 5-HT 1A receptors with anxiolytic activity.In our previous...
The strategy in research toward the development of more selective neuroleptics is that the dopaminergic system can be more sensitively modulated through pharmacological manipulation of the serotonergic system. A new pharmacologically-active compound combining anxiolytic and antipsychotic action - umespirone - display affinities for the 5-HT 1A and 5-HT 2 receptor site [1].Synthesized...
During the last few years, in continuing program to discover antipsychotic and anxiolytic agents we have synthesized in our Department a series of N-substituted cyclic imides and diimides. The highest pharmacological activity - affinity to 5-HT 1A serotonine receptors and activity in behavioral tests - display compounds related to bicyclo[2.2.2]oct-7-ene and bicyclo[2.2.2]octane.Continuing...