Search results for: Barbro Ekstrand-Hammarström

Items from 1 to 10 out of 10 results

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Characterization of toxicological effects of complex nano‐sized metal particles using in vitro human cell and whole blood model systems

Linda Elfsmark, Barbro Ekstrand‐Hammarström, Nina Forsgren, Christian Lejon, more

Journal of Applied Toxicology > 42 > 2 > 203 - 215

Metal oxide fumes form at high temperatures, for instance, during welding or firing ammunition. Inhalation exposure to high levels of airborne metal oxide particles can cause metal fume fever, cardiovascular effects, and lung damage in humans, but the associated underlying pathological mechanisms are still not fully understood. Using human alveolar epithelial cells, vascular endothelial cells, and...

article

The toxic potential of a fourth‐generation E‐cigarette on human lung cell lines and tissue explants

Gregory D. Rankin, Håkan Wingfors, Oskari Uski, Linnéa Hedman, more

Journal of Applied Toxicology > 39 > 8 > 1143 - 1154

The use of electronic cigarettes (E‐cigs) is rapidly increasing. The latest generation of E‐cigs is highly customizable, allowing for high heating coil temperatures. The aim of this study was to assess the toxic potential of a fourth‐generation E‐cig. Aerosols generated from E‐liquid with (24 mg/mL) and without nicotine, using a fourth‐generation E‐cig, were chemically analysed and compared with cigarette...

article

TiO2 nanoparticles tested in a novel screening whole human blood model of toxicity trigger adverse activation of the kallikrein system at low concentrations

Barbro Ekstrand-Hammarström, Jaan Hong, Padideh Davoodpour, Kerstin Sandholm, more

Biomaterials > 2015 > 51 > C > 58-68

There is a compelling need to understand and assess the toxicity of industrially produced nanoparticles (NPs). In order to appreciate the long-term effects of NPs, sensitive human-based screening tests that comprehensively map the NP properties are needed to detect possible toxic mechanisms. Animal models can only be used in a limited number of test applications and are subject to ethical concerns,...

article

The gallium(III)–salicylidene acylhydrazide complex shows synergistic anti-biofilm effect and inhibits toxin production by Pseudomonas aeruginosa

Olena Rzhepishevska, Shoghik Hakobyan, Barbro Ekstrand-Hammarström, Yvonne Nygren, more

Journal of Inorganic Biochemistry > 2014 > 138 > C > 1-8

Bacterial biofilms cause a range of problems in many areas and especially in health care. Biofilms are difficult to eradicate with traditional antibiotics and consequently there is a need for alternative ways to prevent and/or remove bacterial biofilms. Furthermore, the emergence of antibiotic resistance in bacteria creates a challenge to find new types of antibiotics with a lower evolutionary pressure...

article

Large Uptake of Titania and Iron Oxide Nanoparticles in the Nucleus of Lung Epithelial Cells as Measured by Raman Imaging and Multivariate Classification

Linnea Ahlinder, Barbro Ekstrand-Hammarström, Paul Geladi, Lars Österlund

Biophysical Journal > 2013 > 105 > 2 > 310-319

It is a challenging task to characterize the biodistribution of nanoparticles in cells and tissue on a subcellular level. Conventional methods to study the interaction of nanoparticles with living cells rely on labeling techniques that either selectively stain the particles or selectively tag them with tracer molecules. In this work, Raman imaging, a label-free technique that requires no extensive...

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Oxidative stress and cytokine expression in respiratory epithelial cells exposed to well-characterized aerosols from Kabul, Afghanistan

Barbro Ekstrand-Hammarström, Roger Magnusson, Camilla Österlund, Britt M. Andersson, more

Toxicology in Vitro > 2013 > 27 > 2 > 825-833

In this study aerosol samples collected in an Asian mega-city (Kabul, Afghanistan) were compared to PM samples collected in a European location with traffic (Umeå, Sweden) and a reference urban dust material (SRM 1649b). The toxicity of each sample towards normal human bronchial epithelial (NHBE) cells and a human bronchial epithelial cell line (BEAS-2B) was tested along with their ability to induce...

article

Air particles from Kabul induced strong inflammatory response in lung epithelial cells

Barbro Ekstrand-Hammarström, Camilla Österlund, Roger Magnusson, Anders Bucht, more

Toxicology Letters > 2012 > 211 > Supplement > S84

article

Early inflammatory responses to identify biomarkers of chemical-induced lung injury

Sofia Jonasson, Bo Koch, Lina Ågren, Barbro Ekstrand-Hammarström, more

Toxicology Letters > 2012 > 211 > Supplement > S46-S47

article

Inhalation of alkylating mustard causes long-term T cell-dependent inflammation in airways and growth of connective tissue

Barbro Ekstrand-Hammarström, Elisabeth Wigenstam, Anders Bucht

Toxicology > 2011 > 280 > 3 > 88-97

Low-dose exposure of alkylating mustard gas causes long-term respiratory complications characterized by bronchitis and lung fibrosis. In this study, we utilized a mouse model for lung exposure of the nitrogen mustard melphalan, in order to define early and late events in the pathogenesis such as expression of pro-inflammatory cytokines, recruitment of inflammatory cells to airways and late-phase fibrosis...

article

Bacterial and mammalian cell response to poly(3-sulfopropyl methacrylate) brushes loaded with silver halide salts

Madeleine Ramstedt, Barbro Ekstrand-Hammarström, Andrey V. Shchukarev, Anders Bucht, more

Biomaterials > 2009 > 30 > 8 > 1524-1531

This study investigates the antibacterial and cytotoxic effect of surfaces with sulphonate brushes containing silver salts. By using the same type of samples for both cytotoxicity and antibacterial studies, these two parameters could be compared in a controlled way. The silver was incorporated into the brush in four different forms to enable release of silver ions at different concentrations and different...

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