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P2X 7 receptor is an important member of ATP-sensitive ionotropic P2X receptors family, which includes seven receptor subtypes (P2X 1 –P2X 7 ). Recent evidence indicates that P2X 7 R participates in the onset and persistence of neuropathic pain. In tetanic stimulation of the sciatic nerve model, P2X 7 R was involved in the activation of microglia, but whether...
Homeostatic response is an endowed self-correcting/maintaining property for living units, ranging from subcellular domains, single cells, and organs to the whole organism. Homeostatic responses maintain stable function through the ever-changing internal and external environments. In central neurons, several forms of homeostatic regulation have been identified, all of which tend to stabilize the functional...
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