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The tremorgenic alkaloids, paxilline and paspalitrem-C (0.1-10 μM), increased the spontaneous contractility of guinea-pig and rat urinary bladder, and rat duodenum, and induced tension in guinea-pig trachea. These effects are ascribed to blockade of high-conductance, Ca 2+ -activated K + (BK Ca ) channels. Paxilline potentiated the charybdotoxin-induced stimulation...