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High fat, low carbohydrate (HFLC) diets have become popular tools for weight management. We sought to determine the effects of a HFLC diet compared to a low fat high carbohydrate (LFHC) diet on the change in weight loss, cardiovascular risk factors and inflammation in subjects with obesity.Obese subjects (29.0–44.6kg/m 2 ) recruited from Boston Medical Center were randomized to a hypocaloric...