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CBP plays a central role in coordinating and integrating multiple signaling pathways. Competition between NF-κB and p53 for CBP is a crucial determinant of whether a cell proliferates or undergoes apoptosis. However, how the CBP-dependent crosstalk between these two transcription factors is regulated remains unclear. Here, we show that IKKα phosphorylates CBP at serine 1382 and serine 1386 and consequently...
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