Search results for: Katarzyna Kościelska-Kasprzak

Items from 1 to 13 out of 13 results

article

Post-transplant Alternative Complement Pathway Activation Influences Kidney Allograft Function

Dorota Bartoszek, Oktawia Mazanowska, Katarzyna Kościelska-Kasprzak, Agnieszka Lepiesza, more

Archivum Immunologiae et Therapiae Experimentalis > 2019 > 67 > 3 > 171-177

The complement system is one of the crucial pathophysiological mechanisms that directly influence the function of a transplanted kidney. Since the complement pathways’ activation potential can be easily determined via their functional activity measurement, we focused on fluctuation in the cascade activity in the early post-transplant period. The aim of the study was to relate the kidney transplantation-induced...

article

Platelets function assessment in patients qualified for cardiac surgery – clinical problems and a newer diagnostic possibilities

Kinga Kosiorowska, Marceli Lukaszewski, Jacek Jakubaszko, Katarzyna Kościelska-Kasprzak, more

Journal of Cardiothoracic Surgery > 2018 > 13 > 1 > 1-10

Background As the incidence of cardiovascular diseases increases, the use of antiplatelet therapy is widely recognized. This presents clinicians with the challenge of balancing the risk of thrombotic and bleeding complications. Platelet dysfunction is one of the causes of postoperative bleedings and their etiology is not fully understood. Platelets receptors point-of-care investigation is of a remarkable...

article

Antibodies against monomeric C-reactive protein – a promising biomarker of lupus nephritis?

Katarzyna Jakuszko, Magdalena Krajewska, Katarzyna Kościelska-Kasprzak, Marta Myszka, more

Clinical Biochemistry > 2017 > 50 > 13-14 > 756-762

A significant incidence of systemic lupus erythematosus (SLE), the severity of lupus nephritis and varying responses to treatment rationalize the search for novel biomarkers of disease activity.The aim of the study was to assess whether antibodies against monomeric C reactive protein (anti-mCRP) are associated with the presence of lupus nephritis, correlate with disease activity, and whether they...

article

Immune activation‐ and regulation‐related patterns in stable hand transplant recipients

Dorota Kamińska, Katarzyna Kościelska‐Kasprzak, Magdalena Krajewska, Adam Chełmoński, more

Transplant International > 30 > 2 > 144 - 152

We assessed cell subsets and expression of a set of genes related to the T‐cell populations in peripheral blood mononuclear cells to elucidate whether immune status of stable hand transplant recipients (HTx) differs from stable kidney transplant recipients (KTx). The study was conducted on five HTx 4.8 ± 1.7 years after transplantation and 30 stable KTx 7.9 ± 2.4 years after transplantation as well...

article

How different cystoscopy methods influence patient sexual satisfaction, anxiety, and depression levels: a randomized prospective trial

Wojciech Krajewski, Katarzyna Kościelska-Kasprzak, Joanna Rymaszewska, Romuald Zdrojowy

Quality of Life Research > 2017 > 26 > 3 > 625-634

Purpose Bladder cancer (BC) is one of the most common cancers worldwide. BC diagnosis and surveillance is based on cystoscopy (CS). CS impact on patient’s depression, anxiety, and sexual satisfaction (SS) is not sufficiently studied. There are no data on patient’s comfort with flexible or rigid CS. Methods We prospectively evaluated pain perception (PP), depression, anxiety, and SS of 100 male patients...

article

CD4⁺CD25⁺CD127⁻ and CD4⁺CD25⁺Foxp3⁺ Regulatory T Cell Subsets in Mediating Autoimmune Reactivity in Systemic Lupus Erythematosus Patients

Marcelina Żabińska, Magdalena Krajewska, Katarzyna Kościelska-Kasprzak, Katarzyna Jakuszko, more

Archivum Immunologiae et Therapiae Experimentalis > 2016 > 64 > 5 > 399-407

The available clinical as well as experimental studies implicate participation of T regulatory (Treg) subsets in the pathogenesis and course of systemic lupus erythematosus (SLE). Introduction of the CD4⁺CD25⁺CD127⁻ and CD4⁺CD25⁺Foxp3⁺ regulatory subpopulations analysis into immunological processes assessment and disease activation prognosis in patients with lupus nephritis (LN) may improve monitoring...

article

Increased Granulocyte Heparanase Activity in Neutrophils from Patients with Lupus Nephritis and Idiopathic Membranous Nephropathy

Maciej Szymczak, Jakub Kuźniar, Wacław Kopeć, Marcelina Żabińska, more

Archivum Immunologiae et Therapiae Experimentalis > 2017 > 65 > 1 > 83-91

Heparanase is a β-glucuronidase that cleaves sugar chains of heparan sulfate proteoglycans. It is believed that heparanase may be involved in the pathogenesis of proteinuria. The aim of this study was to assess the significance of heparanase in the pathogenesis of particular glomerulonephritis types. The evaluation of heparanase activity in serum, urine, and granulocytes and superoxide dismutase (SOD)...

article

The influence of non‐HLA antibodies directed against angiotensin II type 1 receptor (AT1R) on early renal transplant outcomes

Mirosław Banasik, Maria Boratyńska, Katarzyna Kościelska‐Kasprzak, Dorota Kamińska, more

Transplant International > 27 > 10 > 1029 - 1038

Non‐HLA antibodies (Abs) targeting vascular receptors are thought to have an impact on renal transplant injury. Anti‐angiotensin II type 1‐receptor‐activating antibodies (anti‐AT1R) have been mentioned to stimulate a severe vascular rejection, but the pretransplant screening has not been introduced yet. The aim of our study was to assess the incidence and importance of anti‐AT1R antibodies and their...

article

Humoral immunity in hand transplantation: Anti-HLA and non-HLA response

Mirosław Banasik, Jerzy Jabłecki, Maria Boratyńska, Dorota Kamińska, more

Human Immunology > 2014 > 75 > 8 > 859-862

Antibodies against donor’s HLA antigens and B cell activity are recognized modulators of immune response to allograft. The role of both anti-HLA and non-HLA antibodies is understood in solid organ transplantation, but has not been addressed in composite tissue allografts.We decided to evaluate the presence and role of anti-HLA and non-HLA antibodies after hand transplantation.We assayed anti-HLA and...

article

The impact of non-HLA antibodies directed against endothelin-1 type A receptors (ETAR) on early renal transplant outcomes

Mirosław Banasik, Maria Boratyńska, Katarzyna Kościelska-Kasprzak, Magdalena Krajewska, more

Transplant Immunology > 2014 > 30 > 1 > 24-29

Non-HLA antibodies (Abs) targeting vascular receptors are considered to have an influence on renal transplant injury. Anti-endothelin-1 type A receptor (anti-ETAR) antibodies were associated with cellular and antibody-mediated rejection and early onset of vasculopathy in heart transplant patients but their role in renal transplantation remains unclear. The aim of our study was to assess the incidence...

article

The Complement Cascade and Renal Disease

Katarzyna Kościelska-Kasprzak, Dorota Bartoszek, Marta Myszka, Marcelina Żabińska, more

Archivum Immunologiae et Therapiae Experimentalis > 2014 > 62 > 1 > 47-57

Serum complement cascade, a part of innate immunity required for host protection against invading pathogens, is also a mediator of various forms of disease and injury. It is activated by classical, lectin, and alternative pathways that lead to activation of C3 component by C3 convertases, release of C3b opsonin, C5 conversion and eventually membrane attack complex formation. The tightly regulated...

article

The influence of CTLA-4 gene polymorphism on long-term kidney allograft function in Caucasian recipients

Mariusz Kusztal, Katarzyna Kościelska-Kasprzak, Dominika Drulis-Fajdasz, Maria Magott-Procelewska, more

Transplant Immunology > 2010 > 23 > 3 > 121-124

The aim of the study was to examine whether CTLA-4 (CD152) and CD28 gene polymorphisms affect the outcome of kidney transplantation (KTx). Polymorphisms of the CTLA-4 gene (−318 C>T, +49 A>G, and the microsatellite polymorphism in the 3′UTR of exon 4 (AT) _n ) and a CD28 gene (IVS3 +17T>C) were investigated in 314 allograft recipients with a mean age of 41.9±12years. The median time...

article

Selection of potent chymotrypsin and elastase inhibitors from M13 phage library of basic pancreatic trypsin inhibitor (BPTI)

Liliana Kiczak, Monika Kasztura, Katarzyna Koscielska-Kasprzak, Michal Dadlez, more

Biochimica et Biophysica Acta (BBA)/Protein Structure and Molecular Enzymology > 2001 > 1550 > 2 > 153-163

The combinatorial approach offered by phage display has proved to be powerful in obtaining novel variants of canonical inhibitors of serine proteinases that show new binding patterns. We applied this strategy to search for variants of basic pancreatic trypsin inhibitor (BPTI) that would be strong inhibitors of two serine proteinases: bovine α-chymotrypsin and porcine pancreatic elastase. BPTI only...

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Keywords

ANTIBODY MEDIATED REJECTION (2)
HAND TRANSPLANTATION (2)
HUMORAL REJECTION (2)
KIDNEY TRANSPLANTATION (2)
LUPUS NEPHRITIS (2)
NON-HLA ANTIBODIES (2)
RENAL TRANSPLANT INJURY (2)
RENAL TRANSPLANTATION (2)
SYSTEMIC LUPUS ERYTHEMATOSUS (2)
AGGREGOMETRY (1)
ALTERNATIVE PATHWAY (1)
ANGIOTENSIN II TYPE 1 RECEPTOR ANTIBODIES (1)
ANTI-HLA ANTIBODIES (1)
ANTIBODY‐MEDIATED REJECTION (1)
ANXIETY (1)
AUTOANTIBODIES (1)
BLADDER CANCER (1)
C-REACTIVE PROTEIN (1)
CD28 (1)
COMPLEMENT CASCADE (1)
CTLA-4 (1)
CYSTOSCOPY (1)
CYTOKINES (1)
DEPRESSION (1)
ETAR ABS (1)
FLOW CYTOMETRY (1)
FUNCTIONAL COMPLEMENT ACTIVITY (1)
FUNCTIONAL SELECTION (1)
GENE EXPRESSION (1)
GENE POLYMORPHISM (1)
GLOMERULAR DISEASES (1)
GRANULOCYTES (1)
HEPARANASE (1)
IMMUNOMODULATION (1)
KIDNEY INJURY (1)
KIDNEY RECIPIENTS (1)
KIDNEY TRANSPLANT (1)
LONG-TERM FUNCTION (1)
MULTIPLATE (1)
NON‐HLA ANTIBODIES (1)
PAIN (1)
PHAGE DISPLAY (1)
PLATELET DYSFUNCTION (1)
PLATELET RECEPTORS (1)
PROTEIN INHIBITOR (1)
REGULATORY CELLS (1)
REJECTION (1)
RENAL DISEASE (1)
SERINE PROTEINASE (1)
SEXUAL SATISFACTION (1)
SURVIVAL (1)
T CELLS (1)
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Springer (6)
Elsevier (5)
Wiley (2)

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Search results for: Katarzyna Kościelska-Kasprzak

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