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The present study was conducted to identify effective factors that could induce differentiation of pancreatic ductal epithelial cells (PDECs) into insulin-producing cells. We examined the effect of hepatocyte growth factor (HGF) and betacellulin-δ4 (BTC-δ4) on PDECs. We isolated PDECs from adult rats and stimulated them with HGF and BTC-δ4 for 28days. We observed several characteristics of PDECs after...
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