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DNA mismatch repair (MMR) models have proposed that MSH (MutS homolog) proteins identify DNA polymerase errors while interacting with the DNA replication fork. MLH (MutL homolog) proteins (primarily Mlh1–Pms1 in baker's yeast) then survey the genome for lesion-bound MSH proteins. The resulting MSH–MLH complex formed at a DNA lesion initiates downstream steps in repair. MLH proteins act as dimers and...
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