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J. Neurochem. (2010) 113, 1516–1524.
AbstractNeural stem cells (NSCs) proliferate and generate new neurons in the adult brain. A carbohydrate‐binding protein (lectin), Galectin‐1, is expressed in the NSCs in the subependymal zone (SEZ) of the adult mouse brain. The infusion and knockout of Galectin‐1 in the SEZ results in an increase and decrease, respectively, of NSCs and subsequently born progenitor...
Galectins form a large family of β-galactoside-binding proteins in metazoa and fungi. This report presents a comparative study of the functions of potential galectin genes found in the genome database of Caenorhabditis elegans. We isolated full-length cDNAs of eight potential galectin genes (lec-2–5 and 8–11) from a λZAP cDNA library. Among them, lec-2–5 were found to encode 31–35-kDa polypeptides...
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