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The androgen‐induced alterations in adult rodent skeletal muscle fibre cross‐sectional area (fCSA), satellite cell content and myostatin (Mstn) were examined in 10‐month‐old Fisher 344 rats (n = 41) assigned to Sham surgery, orchiectomy (ORX), ORX + testosterone (TEST; 7.0 mg week−1) or ORX + trenbolone (TREN; 1.0 mg week−1). After 29 days, animals were euthanised and the levator ani/bulbocavernosus...
The effects of testosterone (TEST) treatment on markers of skeletal muscle ribosome biogenesis in vitro and in vivo were examined. C2C12 myotubes were treated with 100 nm TEST for short‐term (24‐h) and longer‐term (96‐h) treatments. Moreover, male 10‐month‐old Fischer 344 rats were housed for 4 weeks, and the following groups were included in this study: (i) Sham‐operated (Sham) rats, (ii) orchiectomised...
Androgens regulate body composition and skeletal muscle mass in males, but the molecular mechanisms are not fully understood. Recently, we demonstrated that trenbolone (a potent synthetic testosterone analogue that is not a substrate for 5-alpha reductase or for aromatase) induces myotrophic effects in skeletal muscle without causing prostate enlargement, which is in contrast to the known prostate...
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