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HIV eludes immune responses that directly target the virus. Previous work in our lab showed that HIV-1 infection leads HLA to present distinct host peptides. We hypothesize that, in the absence of effective HIV-1-specific epitope recognition, host-specific ligands uniquely presented on infected cells can be therapeutically targeted to block transmission of the virus. Our aim is to characterize epitopes...
Class I human leukocyte antigen molecules (A, B and C) reveal intracellular viruses by presenting viral peptide epitopes at the cell surface. At this point the number of viral ligands that decorate the HLA of an infected cell and biases in the targeting of these viral/HLA complexes by cytotoxic T lymphocytes is not understood. Our goal is to determine the number of viral ligands presented by the HLA...