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Chronic inflammatory diseases such as arthritis are characterized by dysregulated responses to pro-inflammatory cytokines such as interleukin-1 (IL-1) and tumor necrosis factor α (TNF-α). Pharmacologic anti-cytokine therapies are often effective at diminishing this inflammatory response but have significant side effects and are used at high, constant doses that do not reflect the dynamic nature of...
Objective
Proinflammatory cytokines such as interleukin‐1 (IL‐1) are found in elevated levels in diseased or injured tissues and promote rapid tissue degradation while preventing stem cell differentiation. This study was undertaken to engineer inflammation‐resistant murine induced pluripotent stem cells (iPSCs) through deletion of the IL‐1 signaling pathway and to demonstrate the utility of these...
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