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The early steps of insulin receptor (IR) signaling (tyrosine phosphorylation of IR β-subunit, IRS-1 and Shc and PI 3'-kinase activity) have been characterized in two target tissues in the chicken: liver and muscle. The signaling cascade appeared to depend on nutritional status in the liver, but not in muscle (with a possible exception for a minor tyrosine phosphorylation of the 52kDa Shc isoform)...