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Diet‐induced obesity is known to impair male reproduction and may aggravate the male reproductive toxicity of the food contaminant acrylamide. Exposure of male mice to acrylamide induces paternally mediated pre‐ and post‐implantation losses because of spermatozoal toxicity and these effects are potentiated in mice fed a high‐fat diet. Glycidamide – an acrylamide metabolite – is the primary mediator...
An increased global prevalence of obesity coincides with an apparent decline in male sperm quality and a possible association between these pathologies has been suggested. In this study, we examined the effects of obesity on sperm chromatin integrity using two mouse models of obesity. In one group of mice, obesity was induced by a high‐fat diet (HFD) (diet‐induced obesity; DIO model), whereas in the...
2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is one of the mutagenic heterocyclic amines derived from cooked meat. In previous animal studies, spontaneous tumour formation in B6 Min/+ mice was associated with somatic loss of the wild-type Apc + allele by loss of the entire chromosome 18 or by recombination. The objective of this study was to examine genetic changes caused...
Metallothionein (MT) is produced at high rates in isolated monocytes, and T and B lymphocytes during induction in vitro. At optimal concentrations, 125 μM for Zn and 10 μM for Cd and dexamethasone (dex), MT was demonstrated after only 2 h in some cases, and in all cell types substantial levels were measured after 1 day of exposure to all three inductors. With Cd, lower amounts of MT were found,...
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