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Breast cancer as a molecularly heterogeneous malignancy is associated with dysregulation of several signaling pathways, including transforming growth factor‐β (TGF‐β) signaling. On the other hand, several recent studies have demonstrated the role of microRNAs (miRNAs) in breast cancer pathogenesis. In the current study, we performed a computerized search to find miR‐206 target genes that are functionally...
BRCA2 is a tumor suppressor gene involved in repair of double strand breaks in DNA. Germ line mutations within this gene are implicated in familial breast and ovary cancer syndromes. Moreover, several studies have assessed association between single nucleotide polymorphisms (SNPs) within this gene and risk of breast cancer. We performed a meta-analysis to assess the association between rs4987117,...
Long non-coding RNAs (lncRNAs) have been shown to participate in the pathogenesis of a variety of cancers including breast cancer. The lncRNA Carbonyl reductase 3-Antisense 1 (CBR3-AS1) has been implicated in some human malignancies in association with androgen receptor (AR). In the present study, we evaluated the expression of CBR3-AS1 and AR transcripts in 52 breast cancer tissues, their corresponding...
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