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The spike protein of SARS‐CoV‐2 exists in two major conformational states, namely the ‘open’ and ‘closed’ states which are also known as the ‘up’ and ‘down’ states, respectively. In its open state, the receptor binding domain (RBD) of the protein is exposed for binding with ACE2, whereas the spike RBD is inaccessible to ACE2 in the closed state of the protein. In the current work, we have performed...