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The aim of this study was to present a new concept of site-directed reduction of disulfide bonds based upon the use of an affinity ligand harbouring a readily oxidizable dithiol. The cysteine bond involved in the acetylcholine binding site of the AChoR was specifically reduced by a carbamylcholine analogue. The ligand, in its oxidized form, was characterized by an affinity constant of 20 μM for the...
Using a solid-phase assay, we found that 3 H-labelled αCobtx from Naja naja siamensis, a long-chain curaremimetic toxin, and 3 H-labelled toxin a from Naja nigricollis, a short-chain toxin both bind specifically but with substantially different affinities (K d = 4.10 -7 M and 50.10 -6 M) to fragment 185-199 (Tα185-199) of the α-subunit of the acetylcholine...
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