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The translocation (11;14)(q13;q32) and its molecular counterpart the BCL-1 rearrangement are features observed in mantle cell lymphoma (MCL) and less commonly in other B-cell disorders. This rearrangement leads to cyclin D1 overexpression, which may be the main pathogenic event in these tumours and is therefore recognised as a diagnostic marker. We developed a flow cytometry method to detect cyclin...
MALT B cell lymphomas with t(1 ;14)(p22;q32) showed a recurrent breakpoint upstream of the promoter of a novel gene, Bc110. Bc110 is a cellular homolog of the equine herpesvirus-2 E10 gene: both contain an amino-terminal caspase recruitment domain (CARD) homologous to that found in several apoptotic molecules. Bc110 and E10 activated NF-κB but caused apoptosis of 293 cells. Bc110 expressed in a MALT...
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