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Ca v 3.2 T-type Ca 2+ channel is required for the activation of calcineurin/NFAT signaling in cardiac hypertrophy. We aimed to investigate how Ca v 3.2 and calcineurin interact. We found that Ca 2+ and calmodulin modulate the Ca v 3.2/calcineurin interaction. Calcineurin binding to Ca v 3.2 decreases the enzyme’s phosphatase activity and diminishes the...
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