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Stem cell therapy is a promising strategy for overcoming the limitations of current treatment methods. The modification of stem cell properties may be necessary to fully exploit their potential. Genetic engineering, with an abundance of methodology to induce gene expression in a precise and well-controllable manner, is particularly attractive for this purpose. There are virus-based and non-viral methods...
The NG2-positive cells are the oligodendrocyte precursors, which, when terminally differentiated, are capable of myelinating the central nervous system. There is however an ever-growing list of evidences that NG2 cells actually possess an intrinsic neurogenic potential and they are capable of neuronal differentiation in response to environmental stimuli. To address the question, we have established...
Cerebrovascular diseases are the leading cause of severe disability worldwide, with an enormous financial burden for society. There is growing evidence that stem cell-based therapy may positively influence recovery from stroke. Cord blood is an attractive source of ontogenetically young, yet safe, stem cells. Conceptually, preclinical studies in which donor cells were of human origin have been the...
Adult bone marrow-derived mesenchymal stem cells (hMSCs) display a spectrum of functional properties. Transplantation of these cells improves the clinical outcome in experimental models of cerebral ischemia and spinal cord injury. Therapeutic effects have been reported in stroke after the systemic delivery of MSCs. A minimally invasive, intraarterial route is an attractive method for stem cell transplantation...
Mesenchymal stem cells (MSC) exert unique ability to differentiate into various cells of mesodermal origin. These properties place MSC as a very promising source of cells for regenerative medicine and tissue engineering. Recently, it has been shown that experimental transplantation of MSC improves a variety of neurological dysfunctions. Bone marrow (BM) represents the mostly exploited source of human...
There is a great interest in the possibility of repairing the nervous system by transplantation new cells that can replace those lost through damage in neurological disorders. Key functions such as the replacement of neural cells have been recently challenged by intrinsic bystander capacities of undifferentiated donor cells to restore these cells. A comprehensive knowledge how transplanted stem cells...
Stem cells have captured considerable scientific and clinic interest because of their potential to renew themselves and to differentiate into one or more adult cell types. Thus stem cells have been recognized as a potential tool for the development of innovative therapeutic strategies in different disease disorders. Stem cells can be discriminating based on their differentiated potential as totipotent,...
The aim of the study was to evaluate therapeutic effectiveness of intra-arterial infusion of human umbilical cord blood (HUCB) derived cells at different stages of their neural conversion. Freshly isolated mononuclear cells (D-0), neurally directed progenitors (D-3) and neural-like stem cells derived from umbilical cord blood (NSC) were compared. Focal brain damage was induced in rats by stereotactic...
Many types of neural progenitors from various sources have been evaluated for therapy of CNS disorders. Prerequisite for success in cell therapy is the ability for transplanted cells to reach appropriate target such as stroke lesion. We have established neural stem cell line from human umbilical cord blood neural stem (HUCB-NSC). In the present study we evaluated migratory capabilities of cells (HUCB-NSC)...
Ischemic stroke remains a major health problem associated with high mortality and severe morbidity. In spite of the extensive research in the field of stroke biology, there is little effective treatment for a completed disease onset. Numerous neuroprotective strategies have failed in clinical trials because of lack of efficacy or unacceptable side-effects. The challenge of clinical trial design is...
Mesenchymal stem cell (MSC) transplantation offers new therapeutic avenue for neurological diseases, however limitted survival of exogenous cells in the host brain is a major setback. The aim of this study was to evaluate the efficacy of using biodegradable scaffolds or Wharton jelly implants contained MSC after their transplantation into rat brain.Materials and methods: Adult Wistar rats were transplanted...
Mesenchymal stem cells (MSC) emerged as promising candidates for therapeutic applications in regenerative medicine and tissue engineering. The ability of MSC to differentiate into multiple different cells of mesodermal origin has offered therapeutic tool for the treatment leukaemias and other malignant diseases. Recently, MSC have been shown to ameliorate a variety of neurological dysfunction. The...
The oligodendrocyte precursors exhibit many features of neural stem cells and constitute the abundant population of dividing progenitors in the young and adult brain. A question arises if their commitment and development could be modulated by either local tissue-specific or neuropathological signals. The aim of our study was to evaluate the effect of distinct microenvironments (provided by either...
Neurotransplantation of allogeneic cells is currently being practiced in double-blinded clinical trials. Overall, the general outcome of these studies has been disappointing and may depend in part upon suboptimal control of host immune response. Immune rejection of allografts has been studied in animal models, but most investigations have been limited to histopathological studies, which can not report...
Mesenchymal stem cells (MSC) are of clinical interest because of their potential use in autologous transplantation. The ability of MSC to differentiate into multiple different cells of mesodermal origin has offered therapeutic tool for the treatment of hematopoietic malignancies and graft versus host disease. Recently, MSC have been shown to ameliorate a variety of neurological dysfunction. This effect...
Over the last decade a large number of studies explored the use of cord-blood-derived stem cells for treatment of neurological disorders. Despite of some positive preclinical results low survival of transplanted cells was noticed in the host brain. It seems that transplantation of the donor cells in their own milieu might be more effective due to the natural cell-cell contact and the presence of growth...
Introduction: Neurological disorders are the most common cause of serious disability and have a major impact on financial healthrelated burden to society. Most of them are definitely associated with cell death: sudden or chronic. Conventional treatment methods yield disappointing results. Thus the discoveries in stem cell biology have fueled the interest in cell-based therapeutical approach. Based...
Cerebral ischemia causes severe functional deficits due to the death of neuronal and glial cells in the cortex and sub-cortical regions. Stem cell-based therapy could be used to restore lost cells and thus may enhance functional recovery. The aim of the study was to compare therapeutic effectiveness of intra-arterial infusion of human umbilical cord-blood derived mononuclear cells (HUCB-MNC) at different...
Studies in experimental stroke demonstrate that cerebral ischemic injury promotes neurogenesis in the subventricular zone (SVZ) and subgranular zone (SGZ) of the dentate gyrus. Spontaneously occurring injury-induced neurogenesis is insufficient to fully reverse disease pathophysiology. Exogenous neural progenitors transplanted into damaged brain might be useful for facilitating the repair of damaged...
Searching for a reliable source of alternative neural stem cells for experimental treatment of neurological disorders we have established neural stem cell line derived from human umbilical cord blood (HUCB-NSC) (Buzanska et al. 2006). These cells have been shown to differentiate along neuronal and glial lineages in the promoting in vitro conditions. In the current study we transplanted HUCB-NSC into...
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