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MDM2 is an oncogene that is frequently over-expressed in various human cancers, including sarcomas, gliomas, melanomas, and breast cancers.1 The primary function of MDM2 is to inhibit the activity of the p53 tumor suppressor protein. P53 inhibits cell proliferation in response to DNA damage and other stresses by activating the transcription of genes that mediate either cell-cycle arrest...
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