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We use a new general-purpose model of neutral evolution of genotypes to make quantitative comparisons of diversity and adaptive evolutionary activity as a function of mutation rate among two versions of Packard’s Bugs model and their neutral shadows. Comparing diversity and evolutionary activity of all these models across the mutation rate spectrum shows that the generic neutral model may have broad...
The Caenorhabditis elegans MES proteins are key chromatin regulators of the germline. MES-2, MES-3, and MES-6 form the C. elegans Polycomb repressive complex 2 and generate repressive H3K27me3. MES-4 generates H3K36me3 on germline-expressed genes. Transcript profiling of dissected mutant germlines revealed that MES-2/3/6 and MES-4 cooperate to promote the expression of germline genes and repress the...
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