Search results for: Agnieszka Klupczyńska

Items from 1 to 14 out of 14 results

article

Population Pharmacokinetic Model of Dexmedetomidine in a Heterogeneous Group of Patients

Justyna Ber, Paweł Wiczling, Marcin Hołysz, Agnieszka Klupczyńska, more

The Journal of Clinical Pharmacology > 60 > 11 > 1461 - 1473

Dexmedetomidine is a hepatically eliminated drug with sedative, anxiolytic, sympatholytic, and analgesic properties that has been increasingly used for various indications in the form of a short or continuous intravenous infusion. This study aimed to propose a population pharmacokinetic (PK) model of dexmedetomidine in a heterogeneous group of intensive care unit patients, incorporating 29 covariates...

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Population analysis to assess the influence of age and body weight on pharmacokinetics and pharmacodynamics of dexmedetomidine in New Zealand White rabbits

Justyna Warzybok, Agnieszka Bienert, Agnieszka Borsuk‐De Moor, Włodzimierz Płotek, more

Biopharmaceutics & Drug Disposition > 41 > 7 > 307 - 316

The purpose of this work was i) to develop a population pharmacokinetic (PK) and pharmacodynamic (PD) model of dexmedetomidine (DEX) in New Zealand White rabbits, ii) to investigate the influence of the age and weight of the animals on the model parameters, and iii) to assess the linearity of DEX PKs in the examined dose range. This was a prospective, crossover study, using a total of 18 New Zealand...

article

Serum lipidome screening in patients with stage I non-small cell lung cancer

Agnieszka Klupczynska, Szymon Plewa, Mariusz Kasprzyk, Wojciech Dyszkiewicz, more

Clinical and Experimental Medicine > 2019 > 19 > 4 > 505-513

The ability of early lung cancer diagnosis is an unmet need in clinical practice. Lung cancer metabolomic analyses conducted so far have demonstrated several abnormalities in cancer lipid profile providing a rationale for further study of blood lipidome of the patients. In the present research, we performed a targeted lipidome screening to select molecules that show promise for early lung cancer detection...

article

A study of low-molecular-weight organic acid urinary profiles in prostate cancer by a new liquid chromatography-tandem mass spectrometry method

Agnieszka Klupczynska, Szymon Plewa, Natalia Sytek, Wojciech Sawicki, more

Journal of Pharmaceutical and Biomedical Analysis > 2018 > 159 > C > 229-236

Metabolomic studies constantly require high throughput screenings, and this drives development and optimization of methods that include more analytes in a single run, shorten the analysis time and simplify sample preparation. The aim of the study was to develop a new simple and fast liquid chromatography-tandem mass spectrometry-based methodology for quantitative analysis of a panel of ten organic...

article

The concomitant use of lapatinib and paracetamol - the risk of interaction

Agnieszka Karbownik, Edyta Szałek, Katarzyna Sobańska, Tomasz Grabowski, more

Investigational New Drugs > 2018 > 36 > 5 > 819-827

Summary Lapatinib is a tyrosine kinase inhibitor used for the treatment of breast cancer. Paracetamol is an analgesic commonly applied to patients with mild or moderate pain and fever. Cancer patients are polymedicated, which involves high risk of drug interactions during therapy. The aim of the study was to assess the interaction between lapatinib and paracetamol in rats. The rats were divided into...

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Pharmacokinetics of dexmedetomidine during analgosedation in ICU patients

Piotr Smuszkiewicz, Paweł Wiczling, Justyna Ber, Justyna Warzybok, more

Journal of Pharmacokinetics and Pharmacodynamics > 2018 > 45 > 2 > 277-284

Dexmedetomidine (DEX) is a fairly new alfa₂-agonist which has been increasingly used in recent years for analgosedation, mostly because it offers a unique ability of providing both moderate level of sedation and analgesia without respiratory depression. Despite of many papers published, there are still only a few concerning the PK of the drug given as long-term infusion in ICU patients. The aim of...

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Development and validation of HPLC–MS/MS procedure for determination of 3,4,4′,5-tetra-methoxystilbene (DMU-212) and its metabolites in ovarian cancer cells and culture medium

Agnieszka Klupczynska, Anna Maria Sulej-Suchomska, Hanna Piotrowska-Kempisty, Marcin Wierzchowski, more

Journal of Chromatography B > 2017 > 1060 > C > 30-35

The synthetic resveratrol analogue DMU-212 (3,4,4′,5-tetramethoxystilbene) has been shown to possess stronger anticancer activity than resveratrol in a variety of tumour cells. To date, there has been no appropriate procedure that would ensure a reliable data about levels of metabolic products of DMU-212 in cancer cell lines. The purpose of this study was to develop a new procedure for determination...

article

Determination of 16 serum angiogenic factors in stage I non-small cell lung cancer using a bead-based multiplex immunoassay

Agnieszka Klupczynska, Paweł Dereziński, Jan Matysiak, Wojciech Dyszkiewicz, more

Biomedicine & Pharmacotherapy > 2017 > 88 > C > 1031-1037

The aim of the study was to identify significant abnormalities in angiogenic factor profiles occurring at early-stage non-small cell lung cancer (NSCLC). Contrary to the previous studies, our research included patients with only stage I NSCLC, which allowed for estimating the utility of circulating angiogenic factors in early NSCLC detection. The investigation was performed in serum samples collected...

article

Study of early stage non-small-cell lung cancer using Orbitrap-based global serum metabolomics

Agnieszka Klupczynska, Paweł Dereziński, Timothy J. Garrett, Vanessa Y. Rubio, more

Journal of Cancer Research and Clinical Oncology > 2017 > 143 > 4 > 649-659

Purpose The aim of the project was to apply ultra-high-performance liquid chromatography–quadrupole-Orbitrap-high-resolution mass spectrometry for serum metabolite profiling of non-small-cell lung cancer (NSCLC). This Orbitrap-based methodology has been applied for a study of NSCLC potential markers for the first time. Methods After extraction using protein precipitation, sera were separated on...

article

Role of CYP1A1 in the biological activity of methylated resveratrol analogue, 3,4,5,4′-tetramethoxystilbene (DMU-212) in ovarian cancer A-2780 and non-cancerous HOSE cells

Hanna Piotrowska-Kempisty, Agnieszka Klupczyńska, Dorota Trzybulska, Katarzyna Kulcenty, more

Toxicology Letters > 2017 > 267 > C > 59-66

The role of CYP1A1 and CYP1B1 enzymes in the biotransformation and biological activity of the methylated resveratrol analogue, 3,4,5,4′-tetramethoxystilbene (DMU-212) is still elusive. Our recently published data have shown that one of the metabolites of DMU-212, 3′-hydroxy-3,4,5,4′-tetramethoxystilbene (DMU-214) exerts more potent cytotoxic effects in A-2780 ovarian cancer cell line, as compared...

article

Evaluation of serum amino acid profiles’ utility in non-small cell lung cancer detection in Polish population

Agnieszka Klupczynska, Paweł Dereziński, Wojciech Dyszkiewicz, Krystian Pawlak, more

Lung Cancer > 2016 > 100 > C > 71-76

Data from studies performed in Japanese and Korean populations suggest that free amino acid profiles have the potential to aid in non-small cell lung cancer (NSCLC) detection. However, there is still no data regarding abnormalities of free amino acids and their usefulness in NSCLC detection in European populations. The aim of the study was an evaluation of utility of amino acid profiles in NSCLC detection...

article

Determination of low-molecular-weight organic acids in non-small cell lung cancer with a new liquid chromatography–tandem mass spectrometry method

Agnieszka Klupczynska, Szymon Plewa, Wojciech Dyszkiewicz, Mariusz Kasprzyk, more

Journal of Pharmaceutical and Biomedical Analysis > 2016 > 129 > C > 299-309

As compared to other classes of metabolites, determination of organic acids is an underrepresented field in cancer research and till now there has been a lack of appropriate analytical procedure for determination of serum levels of organic acids potentially associated with cancer development. The aim of the study was to develop a new rapid liquid chromatography–tandem mass spectrometry method for...

article

Estimation of drug abuse in 9 Polish cities by wastewater analysis

Agnieszka Klupczynska, Paweł Dereziński, Janusz Krysztofiak, Zenon J. Kokot

Forensic Science International > 2016 > 260 > C > 14-21

The aim of this work was to measure illicit drug residues in raw sewage samples collected from nine Polish cities in order to determine trends in illicit drug use in these urban populations. This is the first study involving an analysis of samples from several sewage treatment plants in Poland and covering such a large population. Concentration of illicit drugs was determined using a high performance...

article

A new method for determination of hyaluronidase activity in biological samples using capillary zone electrophoresis

Jan Matysiak, Paweł Dereziński, Bartosz Urbaniak, Agnieszka Klupczyńska, more

Biomedical Chromatography > 27 > 8 > 1070 - 1078

The aim of the study was to develop a new capillary zone electrophoresis (CZE) method for determination of enzymatic activity of hyaluronidase. The method permits monitoring of the process of hyaluronic acid digestion by hyaluronidase. Studies were performed using CZE instrument equipped with capillary of 64.5 cm total length, 56 cm effective length and internal diameter 75 µm. Separation was performed...

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