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Rifampicin is often taken orally over prolonged periods for the treatment of mycobacterial infections. However compliance is poor, resulting in treatment failure and drug resistance. To overcome this problem, biodegradable polylactide(PLA) and polylactide-co-glycolide(PLGA) may be useful in the development of controlled release parenterals containing antimycobacterial drugs. Rifampicin-loaded microspheres...
Mini-matrices containing a model drug, diclofenac sodium, and three natural hydrophilic gum materials, namely karaya, locust bean and xanthan gums were produced. The swelling, erosion and drug release behaviour of these gums for controlled release were investigated and the kinetics analysed. The mini-matrices (4.5mm diameter and 30mg in weight) were compressed using a single punch tablet machine...