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Our previous study (Biomed Pharmacother 2015;69:11) demonstrated that the over-expression of CRKL, a chicken tumor virus number 10 regulator of kinase-like protein, suppresses in vitro proliferation, invasion and migration of murine hepatocarcinoma Hca-P cell, a murine HCC cell with lymph node metastatic (LNM) rate of ∼25%. In current work, we investigated the effects of CRKL knockdown on the in vitro...
When traditional evolution algorithms are used in hardware evolution, it has the disadvantages of slow evolution speed and premature convergence. In order to overcome the shortcomings, a memetic algorithm(MA) that combines the local search method with genetic algorithm is proposed for combinational logic circuit design based on CGP. A gate type local search strategy is proposed in order to be adaptive...
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