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The immunosuppressive characteristics and acquired immune resistance can restrain the therapy‐initiated anti‐tumor immunity. In this work, an antibody free programmed death receptor ligand 1 (PD‐L1) downregulator (designated as CeSe) is fabricated to boost photodynamic activated immunotherapy through cyclin‐dependent kinase 5 (CDK5) inhibition. Among which, FDA approved photosensitizer of chlorin...
Negative therapeutic feedback of inflammation would extensively attenuate the antitumor effect of photodynamic therapy (PDT). In this work, tumor homing chimeric peptide rhomboids (designated as NP‐Mel) are fabricated to improve photodynamic performance by inhibiting PDT‐upregulated cyclooxygenase‐2 (COX‐2). The hydrophobic photosensitizer of protoporphyrin IX (PpIX) and palmitic acid are conjugated...
Vascular diseases (VDs) pose the leading threat worldwide due to high morbidity and mortality. The detection of VDs is commonly dependent on individual signs, which limits the accuracy and timeliness of therapies, especially for asymptomatic patients in clinical management. Therefore, more effective early diagnosis and lesion‐targeted treatments remain a pressing clinical need. Metal–organic frameworks...
A systemic treatment strategy is urgently demanded to suppress the rapid growth and easy metastasis characteristics of breast cancer. In this work, a chimeric peptide‐engineered self‐delivery nanomedicine (designated as ChiP‐CeR) for photodynamic‐triggered breast cancer immunotherapy by macrophage polarization. Among these, ChiP‐CeR is composed of the photosensitizer of chlorine e6 (Ce6) and the TLR7/8...
Anode materials with high‐rate performances and good electrochemical stabilities are urgently required for the grid‐scale application of lithium‐ion batteries (LIBs). Theoretically, transition metal borides are desirable candidates because of their appropriate working potentials and good conductivities. However, the reported metal borides exhibit poor performances owing to their lack of favorable...
Organic luminescent materials are indispensable in optoelectronic displays and solid‐state luminescence applications. Compared with single‐component, multi‐component crystalline materials can improve optoelectronic characteristics. This work forms a series of full‐spectrum tunable luminescent charge‐transfer (CT) cocrystals ranging from 400 to 800 nm through intermolecular collaborative self‐assembly...
Injectable hydrogels find extensive application in the treatment of diabetic wound healing. However, traditional bulk hydrogels are significantly limited due to their nano‐porous structure, which obstructs cell migration and tissue infiltration. Moreover, regulating inflammation and matrix metalloproteinase ‐9 (MMP‐9) expression in diabetic wounds is crucial for enhancing wound healing. This study...
Lymph node metastasis (LNM) is a significant barrier to the prognosis of patients with gastric cancer (GC). Helicobacter pylori (H. pylori)‐positive GC patients experience a higher rate of LNM than H. pylori‐negative GC patients. However, the underlying mechanism remains unclear. Based on the findings of this study, H. pylori‐positive GC patients have greater lymphangiogenesis and lymph node immunosuppression...
Aqueous all‐iron redox flow batteries (RFBs) are promising competitors for next‐generation grid‐scale energy storage applications. However, the high‐performance operation of all‐iron RFBs in a wider temperature range is greatly hindered by inferior iron plating/stripping reaction and low solid–liquid transition temperature at Fe anode. Herein, a universal electrolyte additive design strategy for all‐iron...
Nanodrug delivery systems have demonstrated a great potential for tumor therapy with the development of nanotechnology. Nonetheless, traditional drug delivery systems are faced with issues such as complex synthetic procedures, low reproducibility, nonspecific distribution, impenetrability of biological barrier, systemic toxicity, etc. In recent years, phage‐based nanoplatforms have attracted increasing...
Bimetallic layered double hydroxides (LDHs) are promising catalysts for anodic oxygen evolution reaction (OER) in alkaline media. Despite good stability, NiCo LDH displays an unsatisfactory OER activity relative to the most robust NiFe LDH and CoFe LDH. Herein, a novel NiCo LDH electrocatalyst modified with single‐atom silver grown on carbon cloth (AgSA‐NiCo LDH/CC) that exhibits exceptional OER activity...
Micro/nano‐scaled mechanical metamaterials have attracted extensive attention in various fields attributed to their superior properties benefiting from their rationally designed micro/nano‐structures. As one of the most advanced technologies in the 21st century, additive manufacturing (3D printing) opens an easier and faster path for fabricating micro/nano‐scaled mechanical metamaterials with complex...
Flexible sensors play a crucial role in intelligent electronic devices, while strain‐sensing is the fundamental feature for these sensors of different fields. Therefore, developing high‐performance flexible strain sensors is essential for building the next generation of smart electronics. Here, a self‐powered ultrasensitive strain sensor based on graphene‐based thermoelectric composite threads through...
Nanoheterostructures with exquisite interface and heterostructure design find numerous applications in catalysis, plasmonics, electronics, and biomedicine. In the current study, series core–shell metal or metal oxide‐based heterogeneous nanocomposite have been successfully fabricated by employing sandwiched liquid metal (LM) layer (i.e., LM oxide/LM/LM oxide) as interfacial galvanic replacement reaction...
The pathological aggregation of some proteins is claimed to be highly related to several human diseases, such as β‐amyloid 1–42 (Aβ42) to Alzheimer's disease (AD), islet amyloid polypeptide, and insulin to type 2 diabetes mellitus. Therefore, it is in desperate need to develop effective methods for detection of protein aggregates and inhibition of abnormal aggregation. Herein, to construct all‐in‐one...
Atomically dispersed nitrogen‐coordinated 3d transition‐metal site on carbon support (M‐NC) are promising alternatives to Pt group metal‐based catalysts toward oxygen reduction reaction (ORR). However, despite the excellent activities of most of M‐NC catalysts, such as Fe‐NC, Co‐NC et al., their durability is far from satisfactory due to Fenton reaction. Herein, this work reports a novel Si‐doped...
Sodium Ion Batteries
Metal selenides (MSex) with high theoretical capacity and diverse species have aroused extensive interests. In article number 2206194, Yu Li, Ying Bai, Chuan Wu, and co‐workers comprehensively review the synthesis methods, modification strategies, sodium storage mechanism and recent research progress of various MSex. The effective utilization of MSex anodes will be beneficial...
The powerful and rapid development of lithium‐ion batteries (LIBs) in secondary batteries field makes lithium resources in short supply, leading to rising battery costs. Under the circumstances, sodium‐ion batteries (SIBs) with low cost, inexhaustible sodium reserves, and analogous work principle to LIBs, have evolved as one of the most anticipated candidates for large‐scale energy storage devices...
Photodynamic therapy (PDT) can generate reactive oxygen species (ROS) to cause cell apoptosis and induce immunogenic cell death (ICD) to activate immune response, becoming a promising antitumor modality. However, the overexpressions of indoleamine 2,3‐dioxygenase (IDO) and programmed cell death ligand 1 (PD‐L1) on tumor cells would reduce cytotoxic T cells infiltration and inhibit the immune activation...
Exploiting active and stable non‐precious metal electrocatalysts for alkaline hydrogen evolution reaction (HER) at large current density plays a key role in realizing large‐scale industrial hydrogen generation. Herein, a self‐supported microporous Ni(OH)x/Ni3S2 heterostructure electrocatalyst on nickel foam (Ni(OH)x/Ni3S2/NF) that possesses super‐hydrophilic property through an electrochemical process...
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