Search results for: Ofer Cohen

Items from 1 to 15 out of 15 results

article

Coronal mass ejections and exoplanets: A numerical perspective

Julián D. Alvarado‐Gómez, Jeremy J. Drake, Ofer Cohen, Federico Fraschetti, more

Astronomische Nachrichten > 343 > 4 > n/a - n/a

Coronal mass ejections (CMEs) are more energetic than any other class of solar phenomena. They arise from the rapid release of up to

10^{33}

erg of magnetic energy mainly in the form of particle acceleration and bulk plasma motion. Their stellar counterparts, presumably involving much larger energies, are expected to play a fundamental role in shaping the environmental conditions around low‐mass stars,...

article

Not a melting pot: Plant species aggregate in their non‐native range

Gisela C. Stotz, James F. Cahill, Jonathan A. Bennett, Cameron N. Carlyle, more

Global Ecology and Biogeography > 29 > 3 > 482 - 490

Aim Plant species continue to be moved outside of their native range by human activities. Here, we aim to determine whether, once introduced, plants assimilate into native communities or whether they aggregate, thus forming mosaics of native‐ and alien‐rich communities. Alien species might aggregate in their non‐native range owing to shared habitat preferences, such as their tendency to establish...

article

Time-Dependent Two-Fluid Magnetohydrodynamic Model and Simulation of the Chromosphere

Qusai Al Shidi, Ofer Cohen, Paul Song, Jiannan Tu

Solar Physics > 2019 > 294 > 9 > 1-21

The Sun’s chromosphere is a highly dynamic, partially ionized region where spicules (hot jets of plasma) form. Here we present a two-fluid MHD model to study the chromosphere, which includes ion–neutral interaction and frictional heating. Our simulation recovers a magnetic-canopy shape that forms quickly, but it is also quickly disrupted by the formation of a jet. Our simulation produces a shock self-consistently,...

article

Protection of vaccinated mice against pneumonic tularemia is associated with an early memory sentinel-response in the lung

Liat Bar-On, Hila Cohen, Uri Elia, Shahar Rotem, more

Vaccine > 2017 > 35 > 50 > 7001-7009

Francisella tularensis is the intracellular bacterial pathogen causing the respiratory life-threatening disease tularemia. Development of tularemia vaccines has been hampered by an incomplete understanding of the correlates of immunity. Moreover, the importance of lung cellular immunity in vaccine-mediated protection against tularemia is a controversial matter. Live attenuated vaccine strains of F...

article

Novel CTL epitopes identified through a Y. pestis proteome-wide analysis in the search for vaccine candidates against plague

Anat Zvi, Shahar Rotem, Ayelet Zauberman, Uri Elia, more

Vaccine > 2017 > 35 > 44 > 5995-6006

The causative agent of Plague, Yersinia pestis, is a highly virulent pathogen and a potential bioweapon. Depending on the route of infection, two prevalent occurrences of the disease are known, bubonic and pneumonic. The latter has a high fatality rate. In the absence of a licensed vaccine, intense efforts to develop a safe and efficacious vaccine have been conducted, and humoral-driven subunit vaccines...

article

A novel live attenuated anthrax spore vaccine based on an acapsular Bacillus anthracis Sterne strain with mutations in the htrA, lef and cya genes

Theodor Chitlaru, Ma'ayan Israeli, Shahar Rotem, Uri Elia, more

Vaccine > 2017 > 35 > 44 > 6030-6040

We recently reported the development of a novel, next-generation, live attenuated anthrax spore vaccine based on disruption of the htrA (High Temperature Requirement A) gene in the Bacillus anthracis Sterne veterinary vaccine strain. This vaccine exhibited a highly significant decrease in virulence in murine, guinea pig and rabbit animal models yet preserved the protective value of the parental Sterne...

chapter

Effect of Disruption of mglA on the Virulence and Immunogenicity of the Francisella tularensis Live Vaccine Strain (LVS)

Ofer Cohen, Galia Zaide, Erez Bar-Haim, Itai Mendelson, more

The Challenge of Highly Pathogenic Microorganisms > 219-227

MglA (Macrophage Growth Locus A) is a pleiotropic transcription factor controlling the expression pattern of more than 100 genes in Francisella novicida, including all the ORFs located on the pathogenicity island. To further probe the role of MglA in the pathogenicity of the related strain Francisella tularensis LVS, we generated a mutant LVS strain in which the mglA locus was disrupted by insertion...

article

A biolayer interferometry-based assay for rapid and highly sensitive detection of biowarfare agents

Adva Mechaly, Hila Cohen, Ofer Cohen, Ohad Mazor

Analytical Biochemistry > 2016 > 506 > C > 22-27

Biolayer interferometry (BLI) is an optical technique that uses fiber-optic biosensors for label-free real-time monitoring of protein–protein interactions. In this study, we coupled the advantages of the Octet Red BLI system (automation, fluidics-free, and on-line monitoring) with a signal enhancement step and developed a rapid and sensitive immunological-based method for detection of biowarfare agents...

chapter

Consequences of Antibiotic Treatment of Francisella tularensis Airways Infections

Erez Bar-Haim, Hila Cohen, Raphael Ber, Ofer Cohen, more

The Challenge of Highly Pathogenic Microorganisms > 207-212

Antibiotics are considered as an effective treatment against Francisella tularensis (FT), the causative agent of Tularemia. In this study we compared the efficacy of two types of antibiotics: the bacteriostatic doxycycline and the bactericidic ciprofloxacin, for protection against intranasal FT-LVS in a mouse infection model. Antibiotic treatments were initiated 24–72 h post- bacterial infection,...

chapter

Proteomic Studies of Bacillus anthracis Reveal In Vitro CO₂-Modulation and Expression During Infection of Extracellular Proteases

Theodor Chitlaru, Orit Gat, Galia Zaide, Haim Grosfeld, more

The Challenge of Highly Pathogenic Microorganisms > 11-22

A comparative proteomic study of secretomes of virulent and avirulent Bacillus anthracis strains in various culturing conditions, including those encountered in the host (high CO₂/bicarbonate), enabled identification of approximately 70 proteins representing collectively more than 99% of the secretome. In-vivo expression of 50 proteins was established by 2-dimension Western-analysis using anti B. anthracis...

article

HtrA is a major virulence determinant of Bacillus anthracis

Theodor Chitlaru, Galia Zaide, Sharon Ehrlich, Itzhak Inbar, more

Molecular Microbiology > 81 > 6 > 1542 - 1559

We demonstrate that disruption of the htrA (high temperature requirement A) gene in either the virulent Bacillus anthracis Vollum (pXO1⁺, pXO2⁺), or in the ΔVollum (pXO1^‐, pXO2^‐, nontoxinogenic and noncapsular) strains, affect significantly the ability of the resulting mutants to withstand heat, oxidative, ethanol and osmotic stress. The ΔhtrA mutants manifest altered secretion of several proteins,...

article

Next generation OP-bioscavengers: A circulatory long-lived 4-PEG hypolysine mutant of F338A-HuAChE with optimal pharmacokinetics and pseudo-catalytic characteristics

Chanoch Kronman, Ofer Cohen, Ohad Mazor, Arie Ordentlich, more

Chemico-Biological Interactions > 2010 > 187 > 1-3 > 253-258

We have shown previously that conjugation of polyethylene glycol (PEG) chains to recombinant human acetylcholinesterase (rHuAChE) results in the extension of its residence time in the circulation of mice and monkeys [1,2]. By profiling the pharmacokinetic behavior of an array of well-defined hypolysine human mutant AChE molecules following PEGylation, we now determine that the duration of these enzyme...

article

Polyethylene-glycol conjugated recombinant human acetylcholinesterase serves as an efficacious bioscavenger against soman intoxication

Chanoch Kronman, Ofer Cohen, Lily Raveh, Ohad Mazor, more

Toxicology > 2007 > 233 > 1-3 > 40-46

Extensive pharmacokinetic studies in both mice and rhesus macaques, with biochemically well defined forms of native and recombinant AChEs from bovine, rhesus and human origin, allowed us to determine an hierarchical pattern by which post-translation-related factors and specific amino-acid epitopes govern the pharmacokinetic performance of the enzyme molecule. In parallel, we demonstrated that controlled...

article

Host-regulated disposition of mammalian AChEs

Chanoch Kronman, Ofer Cohen, Baruch Velan, Avigdor Shafferman

Chemico-Biological Interactions > 2005 > 157-158 > Complete > 51-55

Primates are characterized by a paucity of soluble acetylcholinesterase (AChE) in the circulation at the adult stage, where the predominant circulating cholinesterase is butyrylcholinesterase. In recent years, we subjected recombinant human and bovine acetylcholinesterase to extensive pharmacokinetic studies in mice, an animal system which also displays very low levels of circulating AChE. In this...

article

Bimodal karyotype inCynomorium coccineumL. and its systematic implications

BATIA PAZY, UZI PLITMANN, OFER COHEN

Botanical Journal of the Linnean Society > 1996 > 120 > 3 > 279-281

The presence of a bimodal karyotype inCynomorium coccineum(2n=28) is used to support its separation from Balanophoraceae and the maintenance of Cynomoriaceae as a separate family.

Filter options

Publication date

Last 3 years (1)

Close

Date range setting

Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.

From:

To:
Set your own date range

INFONA - science communication portal

Search results for: Ofer Cohen

Add recipient

Sending message cancelled

Are you sure you want to cancel sending this message?

Send message

Filter options

Publication date

Date range setting

Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.

Publication type

Keywords

Data set

Journal

Reporting an error / abuse

Sending the report failed

Accessibility options