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The tumour necrosis factor receptor superfamily (TNFRSF) members contain cysteine‐rich domains (CRD) in their extracellular regions, and the membrane‐distal CRD1 forms homologous interactions in the absence of ligand. The CRD1 is therefore termed a pre‐ligand assembly domain (PLAD). The role of PLAD‐PLAD interactions in the induction of signalling as a consequence of TNF‐TNFR binding led to the development...
Multiplex technologies are becoming increasingly important in biomarker studies as they enable patterns of biomolecules to be examined, which provide a more comprehensive depiction of disease than individual biomarkers. They are crucial in deciphering these patterns, but it is essential that they are endorsed for reliability, reproducibility and precision. Here we outline the theoretical basis of...
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