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IntroductionGrapefruit juice can increase or decrease the systemic exposure of myriad oral medications, leading to untoward effects or reduced efficacy. Furanocoumarins in grapefruit juice have been established as inhibitors of cytochrome P450 3A (CYP3A)‐mediated metabolism and P‐glycoprotein (P‐gp)‐mediated efflux, while flavonoids have been implicated as inhibitors of organic anion transporting...
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